Job Title: Postdoctoral scientist
Job Number: 69954
Location: New York City, US
Located in northern Manhattan, Columbia University Irving Medical Center (CUIMC) is comprised of the College of Dental Medicine, the School of Public Health, the School of Nursing, the Vagelos College of Physicians and Surgeons, and New York Presbyterian Hospital. Together, these institutions comprise a tertiary teaching and research facility that is affiliated with many international medical education institutions and hospital centers. It provides world-class leadership in scientific research, education in life sciences, health and medicine, and patient care. With a workforce of more than 9,000 investigators, faculty, and staff, CUIMC provides ample opportunities for scientific interactions.
The Owusu-Ansah laboratory at the Department of Physiology and Cellular Biophysics in the CUIMC is seeking a highly motivated postdoctoral scientist to study the regulation of mitochondrial complex I (CI) assembly (see Murari et al., 2022, Science Advances and Murari et al., 2023, Cell Reports). The laboratory employs a combination of blue native polyacrylamide gel electrophoresis (BN-PAGE), in-gel oxidative phosphorylation (OXPHOS) activity assays, Western blots, proteomics, RNA-Seq and a range of physiology and cell biology assays to dissect the function of CI. To address this question, our studies have been directed at devising a model system in which we can rigorously examine how CI is assembled, examine the roles of its multiple subunits in bioenergetics and physiology, perform genetic screens to identify new regulators of CI assembly, and create and study various rare CI disease models. While these studies are pursued in fruit flies (Drosophila melanogaster), we anticipate confirming our findings in mammalian systems.
Overview of job responsibilities
1. Design, plan and execute well-thought-out experiments to advance projects.
2. Help with the supervision of technicians and summer undergraduate students to develop mentoring skills.
3. Keep up-to-date with literature related to mitochondrial biology and stress responses.
4. Contribute to the preparation of manuscripts for publication.
1. An MD, PhD or equivalent in cell biology, genetics, biochemistry or other life sciences and be either a US citizen or permanent resident.
2. A track record of excellent publications.
3. Prior experience in assessing mitochondrial health by BN-PAGE, OXPHOS activity assays, oxygen consumption assays, confocal microscopy, proteomics or transcriptomics is strongly desired.
4. Self-driven with the ability to function independently but also as part of a team.
5. Strong interpersonal skills.
Salary and benefits will be commensurate with NIH guidelines. Interested applicants should send a cover letter together with a CV and contact information for three referees to Dr. Edward Owusu-Ansah at [Please click the Apply button for the link or email] and [Please click the Apply button for the link or email]. Applications submitted before December 15, 2023 will be prioritized.
Application Deadline: 2024-04-30