Company:  Confidential

Job Title: Postdoctoral Research Scholar

Job Number: 79466

Location: Iowa City, US

Job Description

The Department of Biochemistry and Molecular Biology is recruiting for a Postdoctoral Research Scholar. This fully funded position is available immediately to study signal transduction in Staphylococcus aureus in a collaboration between the labs of Dr. Ernesto Fuentes (Biochemistry and Molecular Biology) in the Carver College of Medicine at the University of Iowa and Dr. Alexander Horswill (Immunology and Microbiology, University of Colorado-Denver). This exciting NIH-funded project seeks to understand the mechanism(s) by which two-component signal transduction systems in S. aureus sense stimuli and respond to and regulate gene transcription and pathogenesis.


Previous and ongoing research has identified the SrrAB two-component system as critical for S. aureus to survive in a host and for its pathogenesis. We seek a postdoctoral fellow to perform biochemical, biophysical, and structural studies with the aim of deciphering the mechanisms that regulate the S. aureus SrrB sensor histidine kinase (see publication in PNAS). The environment in the Fuentes and Horswill labs is highly collaborative and interdisciplinary. The successful candidate will be integrated into a multi-disciplinary team that combines biochemistry, structural biology, microbiology, cell biology, biophysics, and animal models of infection.


The Biochemistry and Molecular Biology has a highly supportive and collaborative environment with weekly Departmental seminar series and journal clubs. Duties will involve purifying proteins, establishing biochemical activity assays, structural characterization of proteins and complexes using solution NMR, X-ray crystallography and Cryo-EM, maintenance of electronic records, troubleshooting experiments, training research assistants, and contributing to the writing of scientific papers and grant proposals.


Education Requirement: Interested applicants must have (or soon expect to have) a Ph.D. in a field that involves biochemistry, microbiology, or structural biology.


Required Qualifications: A strong background in protein expression, purification, and structural characterization (X-ray, Cryo-EM, or NMR). Ability to design experiments independently and in partnership with the PI and other lab members. In addition, excellent written and verbal communication skills and a strong publication record is expected.


Desirable Qualifications: Expertise in bacteriology is desired, but not required.



To apply, please send the following materials to [Please click the Apply button for the link or email]


Curriculum Vita

Name and Contact Information of References

Letters of Interest

Number of References:  3


Application Deadline: 2024-06-24


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