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Stealth NewCo Gene Editing & Delivery

Job Title: Sr. Scientist, Viral Molecular Biology and Biochemistry

Job Number: 30762

Location: Boston, Massachusetts

Job Description

Sci.bio has partnered with an exceptionally well funded, gene-therapy stealth co aiming to unlock the full potential of gene therapy based on
a novel delivery platform coupled with proprietary CRISPR gene editing technology . This is not your average start-up and is founded by a prominent, world-class leadership team and Board of Directors.

 What makes us different? Over the last decade significant progress has been made in developing powerful technologies for genomic medicines. However, one major challenge for gene therapies remains: the effective and safe delivery of genetic information to patients. Our modular gene delivery platform, derived from the human genome, allows us to package and deliver therapeutic payloads safely into the human body. Together with compact CRISPR gene editors, our approach positions us to overcome these challenges and transform the way genomic medicines are developed and deployed.  

 We are founded by a world leader in CRISPR technologies, with a best in class Board of Directors, and funded by investors committed to our mission.  

 We are seeking energetic, motivated scientists to join our team in developing these new technologies and who are unwavering in their commitment to making an impact on patients’ lives. As an early member, you will help shape our scientific foundation and company culture.

Overview
We are seeking a motivated and enthusiastic Ph.D.-level scientist with in-depth knowledge of molecular biology or protein biochemistry methodologies to be a part of an early discovery biology group to develop a novel therapeutics delivery platform. For this position, a successful candidate will work with and has the potential to lead a small group of junior scientists to generate and experimentally validate innovative approaches to improve gene delivery using endogenous viral-like particles (VLPs).

Responsibilities

  • Work together with a team of scientists in a collaborative environment, sharing in the use of technical skills in biochemistry, protein engineering, and assay development to build a novel viral-like particle (VLP) system for gene editing delivery

  • Deploy advanced biochemical tools to characterize novel VLP features, optimize purification, screen to optimize buffer conditions for VLP formation & cargo loading, and engineer VLP protein for use in cellular delivery

  • Use of structural biology and related computational tools to guide the engineering and characterizing of VLPs

  • Advanced protein biochemistry and engineering, including macromolecular quantification and characterization using biochemical techniques such as TEM, DLS, cryo-EM, SDS-PAGE, western blotting, ELISA, qPCR, etc

Required Skills

  • Ph.D. or equivalent in a life science discipline and 3 or more years of post-graduate work experience

  • Direct experience with the various structural biology methods such as TEM, DLS, protein crystallography, NMR spectroscopy, or cryo-electron microscopy

  • Extensive experience with biochemical characterization, assay development, VLP/AAV/LV production and transduction, molecular biology including western blotting, ELISA, and liquid chromatography

  • Protein and capsid engineering 

  • Experience working in a gene therapy company with similar responsibilities is a plus

  • Excellent oral and written communication skills

  • Demonstration of detailed record keeping and data documentation

  • Strong inter-personnel skills

Our Stealth NewCo is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics. Valuing respect, curiosity and inclusivity is required. IND-1 

 

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