• Full Time (Salaried)
  • ,

Company:  Confidential

Job Title: Sr./Principal Scientist, Vivo Bioanalytics, Gene Therapy Research

Job Number: 34826

Location:

Job Description

The Senior/Principal Scientist in Gene Therapy Research plays a crucial role in developing AAV-based gene therapies for metabolic diseases. Responsibilities include designing, managing, executing, analyzing, and reporting non-GLP and GLP in vivo studies to assess delivery, efficacy, safety, and pharmacology of AAV-gene therapy candidates in animal models. This role also involves overseeing assay development internally and with CROs to achieve program goals collaboratively.

Responsibilities

  • Collaborate with teams and CROs for in vivo study planning and execution.
  • Provide scientific oversight for assay development and sample analysis.
  • Coordinate logistics and manage bioanalytic analyses completion.
  • Consolidate data for study reports and assist in GLP audits.
  • Develop timelines for internal and external deliverables.
  • Contribute to pipeline projects' early proof of concept.
  • Prepare reports, protocols, and presentations.
  • Train and mentor junior scientists.
  • Conduct bioanalytic assays for AAV gene therapy immunotolerability assessment.
  • Ensure compliance with regulations and company policies.

Required Skills

  • PhD in biology, molecular biology, physiology, or related field OR Master’s degree with 10-12 years industry experience.
  • 5-10 years post-PhD experience in academia or industry, preferably in biotech or pharmaceuticals.
  • Experience in planning and managing animal studies.
  • Familiarity with preclinical and bioanalytical CROs.
  • Proficiency in developing bioanalytical assays for AAV gene therapy.
  • Skills in molecular and cellular biology techniques.
  • Preferred experience in metabolic diseases and progressing programs to IND/CTA.
  • Track record of professional growth and problem-solving.
  • Strong organizational, communication, and teamwork abilities.
  • Ethical standards and professionalism.
  • Limited travel (<10%) may be required.

 

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