• , US

Company:  Confidential

Job Title: Sr./Principal Scientist, Vivo Bioanalytics, Gene Therapy Research

Job Number: 78525

Location: , US

Job Description

The Senior/Principal Scientist in Gene Therapy Research plays a crucial role in developing AAV-based gene therapies for metabolic diseases. Responsibilities include designing, managing, executing, analyzing, and reporting non-GLP and GLP in vivo studies to assess delivery, efficacy, safety, and pharmacology of AAV-gene therapy candidates in animal models. This role also involves overseeing assay development internally and with CROs to achieve program goals collaboratively.

Responsibilities

* Collaborate with teams and CROs for in vivo study planning and execution. * Provide scientific oversight for assay development and sample analysis. * Coordinate logistics and manage bioanalytic analyses completion. * Consolidate data for study reports and assist in GLP audits. * Develop timelines for internal and external deliverables. * Contribute to pipeline projects’ early proof of concept. * Prepare reports, protocols, and presentations. * Train and mentor junior scientists. * Conduct bioanalytic assays for AAV gene therapy immunotolerability assessment. * Ensure compliance with regulations and company policies.

Required Skills

* PhD in biology, molecular biology, physiology, or related field OR Master’s degree with 10-12 years industry experience. * 5-10 years post-PhD experience in academia or industry, preferably in biotech or pharmaceuticals. * Experience in planning and managing animal studies. * Familiarity with preclinical and bioanalytical CROs. * Proficiency in developing bioanalytical assays for AAV gene therapy. * Skills in molecular and cellular biology techniques. * Preferred experience in metabolic diseases and progressing programs to IND/CTA. * Track record of professional growth and problem-solving. * Strong organizational, communication, and teamwork abilities. * Ethical standards and professionalism. * Limited travel (<10%) may be required.

Application Deadline: 2024-06-03

 

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