Company: Confidential
Job Title: Sr. Associate Scientist/Principal Associate Scientist, Platform Biology
Job Number: 35891
Location: ,
Job Description
The Senior/Principal Associate Scientist will support the development of novel siRNA designs to enhance activity and specificity for RNAi-based therapeutics. This role involves collaborating across teams to optimize key siRNA features, including structure, design, and chemistry. The position is lab-based, requiring expertise in techniques such as cell culture, molecular biology (qPCR, DNA/RNA extraction, etc.), and biochemistry (enzyme kinetics, assay development, etc.).
Responsibilities
- Contribute to the development of next-generation RNAi platforms by building on existing knowledge of RNAi trigger mechanisms.
- Conduct literature reviews to identify design and chemical modifications for enhancing RNAi therapeutics.
- Perform in vitro and biochemical assays to evaluate, troubleshoot, and optimize siRNA activity and specificity.
- Collaborate with screening and disease-focused teams to support lead optimization through cell-based assays.
- Present experimental plans and findings in team meetings.
- Document experimental procedures and results in an electronic lab notebook (ELN).
Required Skills
- B.S. or M.S. in Biology, Pharmacology, Biochemistry, or a related field with at least 3 years (M.S.) or 5 years (B.S.) of post-graduate experience.
- Proficiency in mammalian cell culture and sterile technique in a BSL2 environment required.
- Experience in RNAi or RNA biology is beneficial.
- Knowledge of NGS library preparation is a plus.
- Familiarity with biochemical methods for analyzing RNA-protein interactions is advantageous.
- Experience with high-throughput techniques and protein purification is desirable.
- Strong communication skills and ability to work both independently and collaboratively.
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