Job Title: Senior Scientist Pulmonary Biology
Job Number: 22312
Location: Lexington, MA
Translate Bio is seeking an experienced Senior Scientist to join our growing Target Biology team. The individual in this role will contribute to drug discovery efforts at Translate Bio, particularly focused on lung diseases with high unmet need. He/She will conduct hands-on research to identify and validate new target opportunities, contribute to our understanding of lung drug delivery and efficacy, and help develop and implement new analytical and therapeutic technologies.
- Lead drug discovery efforts from the bench for various lung diseases by applying Translate Bio’s messenger RNA and lipid nanoparticle platform
- Work with team to identify and validate new target opportunities in pulmonary disease space using in vitro, ex vivo, and in vivo models
- Propose and implement new technologies and strategies to understand disease mechanisms and drug mechanisms of action
- Participate in the mentoring of junior staff
- Assume additional responsibilities as assigned
- Ph.D. in molecular, cell/developmental, pharmacological sciences or similar with an emphasis on lung physiology and pulmonary disease, plus 6+ years post degree experience in academic or industry setting.
- Working knowledge of pathologies, underlying genetics, signaling mechanisms, and cellular injury and repair involved in lung diseases such as idiopathic pulmonary fibrosis.
- Technical hands-on proficiency working with lung cell culture models, specifically primary human bronchial epithelial air-liquid interface (HBE-ALI). Preferred experience delivering lipid-based drugs to these models or general use in drug screening.
- Experience working with and analyzing lung tissue and fluids ex vivo. Analysis includes extracting protein and RNA, cell dissociation, counting, and enrichment. Familiarity with cell markers, flow cytometry, and immunology preferred.
- Possess basic molecular lab skills such as Western Blot, ELISA, and RT-qPCR. Experience with immunofluorescent staining and microscopy favored.
- Ability to clearly document and communicate experimental protocols with strong scientific integrity and desire to contribute at a high-level.