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Job Title: Senior Research Associate / Associate Scientist, Lyophilization Formulation

Job Number: 23219

Location: Lexington, MA

Job Description

We are seeking a highly motivated and scientifically rigorous individual to join the Research and Process Development team as a Senior Research Associate / Associate Scientist. The position will report to the Director of Delivery & Formulations group and will focus on developing lyophilized formulations and executing unique methods required for mRNA formulation characterization and stability testing. 


  1. Support formulation development activities related to lyophilization formulation development
  2. Conduct studies to identify, execute, and evaluate mRNA formulations through stability studies and develop robust lyophilized formulations showing improved stability in refrigerated conditions.
  3. Assist in the formulation and product development activities that may include pre-formulation activities, buffer/excipient screening and selection, developing lyophilized or freeze stable formulations.
  4. Perform stability testing and characterization of routes of degradation of mRNA formulations in liquid and lyophilized formulations under accelerated temperature, refrigerated storage conditions and under different stresses in a variety of containers. Perform analytical assays as needed to assess stability of drug product formulations
  5. Prepare technical reports and presentations for clear communication of scientific findings across interdisciplinary teams

Required Skills

  1. M.S. in Chemistry/Physical Chemistry/Chemical Engineering/Pharmaceutical Sciences 
  2. 1 – 6 years of experience in lyophilization development and stability testing
  3. Hands-on experience of lyophilization process development and lyophilized products in different packaging systems. Prior experience in developing lyophilized nanoparticle formulation is preferred
  4. Extensive experience in stability studies and analytical assays for stability evaluation
  5. Works collaboratively within group as well as within interdisciplinary teams
  6. Manages time effectively demonstrating ability to perform multiple projects at one time
  7. Desire to work in a fast-paced environment
  8. Excellent organizational and communication skills
  9. Strong analytical and problem-solving skills

Translate Bio is committed to equal employment opportunity. All applicants must have authorization to work in the U.S. 


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