Job Title: Senior Investigator/Principal Investigator, Biochemistry
Job Number: 23432
Location: Boston, MA
Silicon Therapeutics is seeking an enthusiastic, motivated and capable individual with expertise in enzymology, biochemistry, assay development and compound screening. Core responsibilities include biochemical assay development, small molecule hit-ID screening and routine testing of compounds in a variety of assays. This is an exciting role for a scientist who is looking to contribute to the discovery and development of cancer therapies. The successful candidate will work as part of a collaborative team of scientists with expertise in protein production and biophysics supporting hit-ID, hit-to-lead, and lead-ID phases of our innate immuno-oncology drug discovery programs and will have the opportunity to mentor and lead more junior scientists.
- Core responsibilities: design and develop in vitro biochemical assays for compound library screening and routine small molecule testing.
- Additional responsibilities could include testing of small molecules in cell-based assays.
- In collaboration with group members, design protein constructs for use in biochemical assays.
- Work as part of a cross-functional project team to provide high-impact results.
- Carefully document research workflows, data and protocols using an electronic laboratory notebook.
- Capture experimental results in database.
- Organize and present data to group members and project team members.
- Mentor and lead more junior scientists within the group.
- Ph.D. with 4+ years (Senior Investigator) or 8+ years (Principal Investigator) of industry experience with a degree in enzymology, biochemistry or related discipline.
- Expertise in in vitro biochemical assay design and development in multiple enzyme formats (FRET, FP, fluorometric, colorimetric, ELISA, etc.), medium-throughput compound library screening, and testing of small molecules for determining inhibition/binding.
- Application of mathematical binding/inhibition models to determine small molecule mechanism of action (cooperativity, competitive/non-competitive, etc).
- Hands-on experience in cell-based assay design and development and testing of small molecules for determining inhibition/cytotoxicity/plasma protein binding.
- Proficient in relevant programs for data analysis and visualization.
- Demonstrated ability to troubleshoot and optimize experiments.
- Demonstrated ability to lead and mentor others.
- Excellent communication skills.
- Experience with proteins that bind to or modify oligonucleotides is a plus.