• Full Time (Salaried)
  • Boston, MA

Job Title: Senior Investigator/Principal Investigator, Biochemistry

Job Number: 23432

Location: Boston, MA

Job Description

Silicon Therapeutics is seeking an enthusiastic, motivated and capable individual with expertise in enzymology, biochemistry, assay development and compound screening. Core responsibilities include biochemical assay development, small molecule hit-ID screening and routine testing of compounds in a variety of assays. This is an exciting role for a scientist who is looking to contribute to the discovery and development of cancer therapies. The successful candidate will work as part of a collaborative team of scientists with expertise in protein production and biophysics supporting hit-ID, hit-to-lead, and lead-ID phases of our innate immuno-oncology drug discovery programs and will have the opportunity to mentor and lead more junior scientists.


  • Core responsibilities: design and develop in vitro biochemical assays for compound library screening and routine small molecule testing.
  • Additional responsibilities could include testing of small molecules in cell-based assays.
  • In collaboration with group members, design protein constructs for use in biochemical assays.
  • Work as part of a cross-functional project team to provide high-impact results.
  • Carefully document research workflows, data and protocols using an electronic laboratory notebook.
  • Capture experimental results in database.
  • Organize and present data to group members and project team members.
  • Mentor and lead more junior scientists within the group.

Required Skills

  • Ph.D. with 4+ years (Senior Investigator) or 8+ years (Principal Investigator) of industry experience with a degree in enzymology, biochemistry or related discipline.
  • Expertise in in vitro biochemical assay design and development in multiple enzyme formats (FRET, FP, fluorometric, colorimetric, ELISA, etc.), medium-throughput compound library screening, and testing of small molecules for determining inhibition/binding.
  • Application of mathematical binding/inhibition models to determine small molecule mechanism of action (cooperativity, competitive/non-competitive, etc).
  • Hands-on experience in cell-based assay design and development and testing of small molecules for determining inhibition/cytotoxicity/plasma protein binding.
  • Proficient in relevant programs for data analysis and visualization.
  • Demonstrated ability to troubleshoot and optimize experiments.
  • Demonstrated ability to lead and mentor others.
  • Excellent communication skills.
  • Experience with proteins that bind to or modify oligonucleotides is a plus.


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