Prime Medicines, Inc.

Job Title: Senior Associate Scientist II, Oligonucleotide Chemistry

Job Number: 33389

Location: Watertown, MA, MA

Job Description

Our client is seeking a passionate scientist and technically accomplished Senior Associate Scientist to join our guide RNA chemistry team and work with an enthusiastic team of highly skilled scientists in a dynamic and high growth company. This is a laboratory-based position, and the successful candidate will have a strong background in oligonucleotide chemistry and support all aspects of synthesis, purification, and characterization of novel guide oligonucleotides to advance our cutting-edge gene editing drug discovery programs. Core competencies include an ability to function in an interdisciplinary and fast-paced startup environment coupled with a proactive and collaborative approach. This position will be based in their Watertown, MA location.


  • High throughput synthesis, purification, and analysis of novel oligonucleotides with various chemical modifications.

  • Operate, maintain & troubleshoot oligonucleotide synthesis platforms (MerMade 12 and Dr. Oligo 48, etc.), HPLCs, LCMS and other scientific equipment.

  • Developing synthesis and downstream processing methods for improved synthesis, purification, and analysis of long oligonucleotides.

  • Track progress, generate regular status updates, and communicate the progress and present data.

  • Write SOPs, maintain a well-documented electronic notebook and internal oligonucleotide inventory.

  • Demonstrate basic lab competency in preparing reagents and buffers & handling chemicals.

  • Capable of repetitive tasks and performing other duties as assigned.

Required Skills

  • BS or BA in Chemistry, Biochemistry, or related fields with 4+ years chemistry laboratory experience in an industrial or academic setting or M.S. in Chemistry, Biochemistry, or related fields with excellent understanding of nucleic acids and analytical chemistry and 2+ years chemistry laboratory experience.

  • Experience in solid-phase synthesis and downstream processing of oligonucleotides is required.

  • Experience in handling, troubleshooting and routine maintenance of critical instrumentation such as automated oligonucleotide synthesizers, HPLCs and LC-MS etc. 

  • Experience working in chemistry laboratory and preparation of phosphoramidite and reagent solutions.

  • High degree of flexibility and self-motivation in a fast-paced work environment and excellent problem-solving skills.

  • Excellent communication and presentation skills.

  • Mentoring co-workers and new team members.

  • Detail-oriented and excellent problem-solving abilities.

  • Basic computer skills including MS Office Suite.


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