Prime Medicines, Inc.
Job Title: Senior Associate Scientist II, Oligonucleotide Chemistry
Job Number: 33389
Location: Watertown, MA, MA
Job Description
Our client is seeking a passionate scientist and technically accomplished Senior Associate Scientist to join our guide RNA chemistry team and work with an enthusiastic team of highly skilled scientists in a dynamic and high growth company. This is a laboratory-based position, and the successful candidate will have a strong background in oligonucleotide chemistry and support all aspects of synthesis, purification, and characterization of novel guide oligonucleotides to advance our cutting-edge gene editing drug discovery programs. Core competencies include an ability to function in an interdisciplinary and fast-paced startup environment coupled with a proactive and collaborative approach. This position will be based in their Watertown, MA location.
Responsibilities
High throughput synthesis, purification, and analysis of novel oligonucleotides with various chemical modifications.
Operate, maintain & troubleshoot oligonucleotide synthesis platforms (MerMade 12 and Dr. Oligo 48, etc.), HPLCs, LCMS and other scientific equipment.
Developing synthesis and downstream processing methods for improved synthesis, purification, and analysis of long oligonucleotides.
Track progress, generate regular status updates, and communicate the progress and present data.
Write SOPs, maintain a well-documented electronic notebook and internal oligonucleotide inventory.
Demonstrate basic lab competency in preparing reagents and buffers & handling chemicals.
Capable of repetitive tasks and performing other duties as assigned.
Required Skills
BS or BA in Chemistry, Biochemistry, or related fields with 4+ years chemistry laboratory experience in an industrial or academic setting or M.S. in Chemistry, Biochemistry, or related fields with excellent understanding of nucleic acids and analytical chemistry and 2+ years chemistry laboratory experience.
Experience in solid-phase synthesis and downstream processing of oligonucleotides is required.
Experience in handling, troubleshooting and routine maintenance of critical instrumentation such as automated oligonucleotide synthesizers, HPLCs and LC-MS etc.
Experience working in chemistry laboratory and preparation of phosphoramidite and reagent solutions.
High degree of flexibility and self-motivation in a fast-paced work environment and excellent problem-solving skills.
Excellent communication and presentation skills.
Mentoring co-workers and new team members.
Detail-oriented and excellent problem-solving abilities.
Basic computer skills including MS Office Suite.
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