Company:  Confidential

Job Title: Scientist/Senior Scientist, Oligonucleotide Chemistry

Job Number: 77883

Location: Cambridge, US

Job Description

As a Senior Scientist specializing in Oligonucleotide Chemistry, you will play a pivotal role in advancing mRNA-based therapeutic programs. Leveraging your expertise in oligonucleotide chemistry, synthesis, purification, scale-up, and post-synthetic bioconjugation, you will contribute to the development of cutting-edge mRNA therapeutics that have the potential to transform patient care.


* Design and implement innovative strategies for the synthesis, purification, and scale-up of oligonucleotides, with a focus on mRNA-based therapeutics.  * Utilize hands-on experience to optimize synthetic routes, purification methods, and bioconjugation protocols for the efficient production of mRNA constructs.  * Lead the development and application of Click Chemistry and other bioconjugation techniques for site-specific modification of mRNA molecules. * Collaborate closely with multidisciplinary teams to integrate oligonucleotide chemistry into the design and optimization of mRNA constructs. * Conduct analytical characterization of mRNA constructs using HPLC, LC-MS, NMR, and other spectroscopic methods. * Mentor junior scientists, providing technical guidance and expertise in oligonucleotide chemistry, mRNA-based therapeutics, and bioconjugation. * Stay abreast of the latest advancements in oligonucleotide chemistry, mRNA technology, and bioconjugation, incorporating relevant innovations into research activities.

Required Skills

* Ph.D. in Chemistry, Biochemistry, or related field with a specialization in oligonucleotide chemistry. * Minimum of 2 to 3 years of hands-on experience in oligonucleotide synthesis, purification, scale-up, and post-synthetic bioconjugation, preferably in an industrial setting.  * Proficiency in mRNA-based therapeutics and a strong understanding of mRNA biology and technology.  * Expertise in Click Chemistry and other bioconjugation techniques, with demonstrated experience in mRNA modification and optimization. * Proficient in analytical techniques such as HPLC, LC-MS, NMR, and spectroscopic methods for mRNA characterization. * Strong problem-solving skills with the ability to optimize synthetic routes, purification methods, and bioconjugation protocols.  * Excellent communication and collaboration skills, with demonstrated leadership abilities in project management and mentoring.  * Passion for scientific innovation and a commitment to advancing mRNA-based therapeutics for the benefit of patients.Join the mission to develop innovative therapies and make a meaningful impact on patients’ lives. They offer competitive compensation, comprehensive benefits, and opportunities for professional growth and development. If you are looking for a new challenge and the opportunity to contribute to cutting-edge science, please join!

Application Deadline: 2024-06-03


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