Scientist, In-Vivo & In-Vitro Pharmacology

Job Title: Scientist, In-Vivo & In-Vitro Pharmacology

Job Number: 35445

Location: Syracuse, NY

Job Description

We are looking for a Scientist in the R&D group. The successful candidate will contribute to drug discovery efforts in the following areas, liver (NASH) and oncology indications. The qualified candidate is a highly motivated, interactive, and creative bench scientist who will conduct experiments utilizing genetically engineered mouse and lab models to advance discovery programs to IND. The successful candidate will demonstrate clear and professional communication, effectively collaborate with colleagues across a highly matrixed environment, and be capable of presenting scientific results to project teams.

Responsibilities

– Design, conduct and advise on pharmacology studies related to complex in vivo and in-vitro
models focused on liver/NASH and cancer diseases.
– Conduct experiments and develop assays critical to understand in-vivo therapeutic activity,
efficacy, and PK/PD properties.
– Designing and executing In-vitro Hepatotoxicity, Cytotoxicity, and Cell Viability assays
– Coordinate and manage studies with Strategic Partners and external collaborators.
– Breeding and colony maintenance of transgenic mouse strains
– Documentation of assay development and in vivo/vitro study results.
– Mentor/manage junior associates and colleagues on best practices in the laboratory.

Required Skills

– Ph.D. in Pharmacology (or related field of study) with 0-1years of industry experience.
– Prior experience designing and executing in vivo studies with murine and rat models a must.
– Ability to use animal models and a variety of high throughput tools including expression
analysis, transcriptional profiling, AAV, in situ hybridization and immunohistochemistry.
– Experience in developing NASH/Oncology based therapeutics is desired.
– Attention to detail with excellent organizational and record keeping skills.
– Ability to work collaboratively across departments, understand and implement applicable
regulations around animal care/safety/handling desired.
– Highly motivated and ability to be flexible in case of changing priorities.
– Strong written and verbal communication skills with the ability to interact effectively with
peers and management. Capable of presenting scientific results to multidisciplinary teams
and key stakeholders.
– Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft
Office etc. for data analysis and figure generation is required.