• Full Time (Salaried)
  • ,

Company:  Confidential

Job Title: Scientist II/Sr. Scientist Ex Viv Islet Biology & Metabolism

Job Number: 34823

Location:

Job Description

The Scientist II/Senior Scientist in Gene Therapy Research is integral to developing AAV-based gene therapies for metabolic diseases. They contribute to lead and pipeline programs through assays, modeling, and screening, requiring expertise in islet biology and a collaborative approach to achieving program goals.

Responsibilities

  • Develop and perform molecular assays for AAV-based gene therapy assessment in islet cells.
  • Contribute to in vivo data through islet isolation and characterization from animal models.
  • Engineer pancreas properties for disease targets.
  • Introduce new technologies and biological concepts to support gene therapy goals.
  • Manage CRO activities for cell model development and islet transgene assessment.
  • Collaborate with teams to achieve program objectives.
  • Prepare technical reports and mentor junior scientists.
  • Ensure compliance with regulations and company policies.

Required Skills

  • PhD in Biology, Physiology, or related field OR Masters with 10+ years industry experience.
  • 3-5+ years post-PhD experience in academia or industry, preferably in biotech or pharmaceuticals.
  • Management or mentorship experience preferred.
  • Extensive experience with primary pancreatic islets.
  • Islet isolation skills preferred.
  • Proficient in mammalian cell culture and cell-based assays.
  • Familiarity with metabolic disease animal models.
  • Skills in Flow Cytometry, Microscopy, IF imaging, ELISA, and molecular biology techniques.
  • Prior gene therapy research is a plus, including transfection and AAV transduction.
  • Experience with CRO collaboration and IND/CTA filing processes advantageous.
  • Track record in dynamic environments with intellectual curiosity and problem-solving skills.
  • Ability to lead projects efficiently and work well in small teams.
  • Strong organizational, communication, and ethical standards.

 

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