Goldfinch Bio

Job Title: Scientist I/II – Biology

Job Number: 22914

Location: Cambridge, MA

Job Description

The Scientist I/II should have strong image acquisition and image analysis skills across a variety of different systems. They will develop, implement and execute in vitro assays required for the advancement of high priority projects and Goldfinch Bio's Product Engine. This position is part of a close-knit team focused on developing cutting edge assays for target validation and compound screening using in vitro models including human-derived kidney organoids.

Responsibilities

  • Development and implementation of a diverse set of cellular assays used to support lead discovery and target validation with an emphasis on image-based assays
  • Develop image analysis methods and maintain imaging systems
  • Design, execute, troubleshoot, and interpret biological experiments in support of program objectives in partnership with scientific leadership
  • Contribute significantly to weekly sample preparation (cryo/paraffin sectioning and staining) and tissue culture work required for pipeline 2D and 3D cellular models
  • Interact and communicate results and conclusions to the biology team and cross-functional project teams

Required Skills

  • B.S. or M.S. in cell and/or molecular biology with minimum of 5 years of pharmaceutical/Industry experience required; or PhD, post-doctoral experience a plus 
  • Significant experience in
    • confocal imaging, high-content imaging; stereology experience desirable
    • cryo- and/or paraffin-sectioning
    • histological and immunofluoimmunrescence techniques
    • variety of image analysis methods (e.g. ImageJ/Fiji, Zen, Elements); familiarity with computational data analysis and/or Amira desirable but not required
  • Experience in cell and biochemical assay development and familiarity with high-throughput screens
  • Experience in biochemistry, molecular biology, and cell biology techniques
  • Extensive and diverse tissue culture experience; iPSC desirable but not required
  • Demonstrated ability to thrive in a team environment
  • Some weekend work will be required

 

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