1-617-500-6690 [email protected]
  • Full Time (Salaried)
  • Boston, MA

Stealth NewCo Gene Editing & Delivery

Job Title: Scientist – Gene Therapy

Job Number: 31390

Location: Boston, MA

Job Description

We are seeking a motivated Scientist, Gene Therapy with deep subject matter expertise in CRISPR-based technologies and therapeutic applications. In this role, you will lead our discovery and gene therapy development efforts, designing and implementing medium- to high-throughput screening assays with genomics and functional readouts in disease-relevant cells. The ideal candidate will have extensive
experience designing, conducting, and analyzing epigenome editing experiments using next generation CRISPR technologies such CRISPRoff. The successful candidate will lead our in vitro gene editing and screening efforts, identifying candidates and guiding them through early development towards IND. You will bring together transformative gene delivery and editing technologies and lead collaboratively from the bench in a fast-paced environment.


● Design and conduct CRISPRi/CRISPRa editing experiments using novel CRISPR epigenome editors in human derived disease models
● Support the development of genomics, epigenomics and functional readouts in disease relevant human derived cell models
● Design and implement high-throughput assays for novel epigenome editors and identify hits for lead optimization
● Act as an expert resource for complex problems and issues
● Communicate findings and results, maintaining laboratory notebooks with scientific integrity
● Support IP development of our Intellectual Property portfolio; prepare reports and manuscripts
● Present results and lead discussions about research strategy with your team and cross-functional groups

Required Skills

● PhD in Molecular Biology or related field with 3+ years of relevant work experience
● Strong candidates with Masters (6-8 years) will also be considered
● Experience in epigenome editing and gene therapy/nucleic acid therapy modalities and/or readout techniques of epigenome modifications (e.g. ATAC-Seq, ChiP-Seq, Bisulfite Seq)
● Experience with medium- to high-throughput screening assays and automation would be a plus
● Knowledge of gene delivery methods including transfection, electroporation, viral and non-viral based methods
● Experienced working with human primary or iPSC-derived cell models; CNS/PNS models would be a plus
● Record of scientific excellence demonstrated by publications of scientific work or industry project experience
● Self-motivated, scientifically rigorous with strong organizational skills; a commitment to keeping accurate, detailed experimental records
● Strong desire to work on early-stage technology development and lead from the bench
● Demonstrated project leadership skills, driving for results and innovation
● Accustomed to effectively communicating progress, needs, and problems.


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