Job Title: Scientist Biophysics
Job Number: 30371
Reporting to the Senior Vice President, Research, the Scientist, Biophysics will be key member of our Research group, responsible for the biophysical and mechanistic characterization of small molecules binding to RNA. The Principal Scientist will integrate a broad understanding of biophysics with RNA dynamics, enzymology, and structural biology with the goal of understanding the molecular mechanism of action and corresponding pharmacology of a diverse set of RNA targets. Industry experience in biophysical biology is essential. This is a hands-on laboratory position based in our Jupiter, Florida research site. *Title will be commensurate with experience.
- Develop, drive and track towards key priorities for biophysics studies across multiple programs
- Design and implement biophysical characterization of RNA-ligand and RNA-protein interactions using an array of biophysical techniques such as BLI, SPR, etc.
- Investigate binding kinetics and characteristics in vitro and in cellular models
- Partner and build strong relationships with team members in structural biology, biochemistry and chemistry to build robust screening paradigms and drive SAR, in order to advance hit-to-lead and
- lead optimization activities.
- Drive deep mechanistic understanding of ligand binding and collaborate with colleagues to integrate this into pharmacology studies, both in vitro and in vivo
- Interpret study results and develop further recommendations for each program
- Independently communicate results in the form of oral presentations and industry-standard study reports
- Prepare reports and presentations for leadership and participate in internal/external meetings
- Make intellectual contributions to all aspects of hit finding and lead discovery
- PhD in biophysics, biochemistry, or a related scientific field.
- Minimum 5 years of industry experience, preferably in the field of RNA biology.
- Experience developing, running, and interpreting biophysical characterizations of small molecules in an industrial setting is essential; hands on experience is required
- Familiarity with key concepts and computational tools related to RNA structure, repeat expansion, alternative splicing, translation, or other areas of RNA biology is strongly preferred.
- Ability to function in a scientific expert role as part of an interdisciplinary team, contributing to the execution of experiments in support of overall research activities and project goals.