Job Title: Scientist Biochemist
Job Number: 30370
Reporting to the Senior Vice President, Research, the Scientist, Biochemistry will be key member of our Research group, responsible for concepting and executing biological studies across multiple programs, with the goal of advancing through hit-to-lead and lead optimization studies. The successful candidate will have a proven track record of success in cell-based assay development and screening. Experience in biochemically confirming target engagement and drug mechanism is essential. This is a hands-on laboratory position based in our Jupiter, Florida research site. *Title will be commensurate with experience.
- Design, build and validate in vitro and cellular assays of RNA binding, transcription, and translation by leveraging molecular and cell biology expertise.
- Support and contribute to analysis of binding kinetics in vitro to confirm on-target pharmacology.
- Design and implement innovative methods to confirm target engagement and on-target biology and explore detailed mechanism of action.
- Influence and support the biochemical analysis of tissues derived from in vivo studies eg RT-qPCR, RNA-Seq, histology, fluorescence, in situ hybridization, biochemical analysis, ELISA etc.
- Partner and develop strong relationships with the drug discovery, structural biology, and pharmacology teams to advance hit-to-lead and lead optimization activities.
- Interpret study results and develop further recommendations for each program
- Independently communicate results in the form of oral presentations and industry-standard study reports.
- PhD in biochemistry, cell biology, or a related scientific field.
- Minimum 5 years of industry experience, preferably in the field of RNA biology or neuroscience.
- Experience developing, running, and interpreting cell-based characterizations of small molecules in an industrial setting is essential e.g., fluorescence-based reporter assays, qPCR splicing assays, etc.; hands on experience is required.
- Demonstrated track record in molecular and cell biology, biochemical analysis, and cellular assay development.
- Familiarity with key concepts related to RNA structure, repeat expansion, alternative splicing, translation, or other areas of RNA biology is strongly preferred.
- Ability to function in a scientific expert role as part of an interdisciplinary team, contributing to the execution of experiments in support of overall research activities and project goals.