Company: Confidential
Job Title: Research Scientist – Mass spectrometry – Ferguson Lab
Job Number: 91042
Location: San Diego, US
Job Description
Background: U.C. San Diego provides an outstanding environment for training, where colleagues include world-class basic scientists, clinical pharmacists and physicians. UCSD provides access to state-of-the art facilities and equipment, and there are abundant opportunities for collaboration with other research groups at UCSD, and at surrounding institutions including Salk, Scripps and Sanford Burnham Prebys.
About: The Ferguson research group is a chemical biology lab in the U. C. San Diego Department of Chemistry & Biochemistry, and the Skaggs School of Pharmacy and Pharmaceutical Sciences. Our research goal is to harness induced proximity create new tools, technologies, and therapeutic approaches for better understanding and treatment of neurological disorders, with a focus on degenerative disease. To accomplish this, we use a broad range of techniques including medicinal chemistry, assay development, mass-spectrometry based proteomics, functional genomics and patient-derived cell models. You can learn more about our research by visiting: https://fergusonlab.ucsd.edu
Position: The Ferguson lab seeks a POSTDOCTORAL FELLOW or RESEARCH SCIENTIST who will work on various mass spectrometry-based proteomics projects involving the development and characterization of molecular glues and related novel modalities that alter the interactome and post-translational modification of protein targets. While we consider various backgrounds, a strong interest in understanding cell signaling, and the desire to tackle a major problem of great significance are absolutely essential. The position will allow the candidate to develop valuable new skills and experience in molecular glue discovery, target validation, targeted protein degradation, and chemical biology in a highly collaborative research environment. Position includes a competitive salary and generous benefits through the UC system.
Our laboratory is based on the UC San Diego main campus and is affiliated with both Physical Sciences and Health Sciences divisions, the ThermoFischer Goedell Family Technology Sandbox, the UC San Diego Shiley-Marcos Alzheimer’s Disease Research Center, the Altman Clinical and Translational Research Institute, the UCSD Moores Cancer Center. We have access to state-of-the-art facilities for chemistry, biophysics, cell biology, imaging and structural biology. The lab also has expertise and equipment access for mass-spectrometry including an Orbitrap Eclipse Tribrid and a timsTOF HT. Join our highly interactive team of scientists, postdocs, graduate students and undergraduate researchers to work on understanding the synthetic signaling circuits created by chemically induced proximity, and leverage these insights to test new avenues for therapeutic development.
Responsibilities:
· Assay development and mechanism of action studies.
· Patient-derived cell culture.
· Collaborate effectively with medicinal chemists in the Ferguson lab, and with translational research groups.
· Supervise and train other researchers in experimental techniques.
· Prepare and write scientific manuscripts, patents, and fellowship applications in collaboration with the principal investigator.
· Attend and present findings at internal, local and national meetings.
Requirements:
· Recent Ph.D. or equivalent degree in biochemistry, analytical chemistry or mass spectrometry.
· Experience in sample preparation for mass spectrometry-based proteomics.
· Strong understanding of statistical analysis.
· Experience with R, python and general computational abilities necessary for mass-spectrometry data analysis.
· Ability to work in a collaborative and team environment.
Application: Please email a cover letter describing relevant experience and research interests, a CV including publication list, and contact information for three references to fmferguson (at) ucsd.edu.
UC San Diego is an Equal Opportunity/Affirmative Action Employer with a strong institutional commitment to excellence through diversity. All qualified applicants will receive consideration for employment without regard to gender, race, color, religion, sex, sexual orientation, national origin, disability, age or protected veteran status.
Application Deadline: 2025-06-01
To apply for this job please visit jobrxiv.org.