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Job Title: Research Associate/Sr. Research Associate – Pulmonary Delivery

Job Number: 25618

Location: Lexington, MA

Job Description

We are seeking a highly motivated and scientifically rigorous individual to join the Delivery and Formulation Development team as a Research Associate /Sr. Research Associate. The position will focus on evaluation and optimization of novel mRNA formulations that can be nebulized for inhalation.

Responsibilities

  • Support formulation development of mRNA Lipid nanoparticles (LNP) for inhalation as a route of administration.
  • Perform experiments to identify critical design parameters for pulmonary delivery of LNP formulations.
  • Provide formulations and perform characterization assays /data analysis with a focus on inhalation drug development.
  • Prepare technical reports and presentations for clear communication of scientific findings across interdisciplinary teams.

Required Skills

  • B.S./M.S. in Chemistry/Physical Chemistry/Chemical Engineering/Biochemistry.
  • 3+ years of relevant experience in drug delivery.
  • Demonstrated success in nucleic acid delivery with hands-on experience in lipid nanoparticle (LNP) formulations, polymer-based nanoparticles & characterization.
  • Prior experience working with OINDP is desired.
  • Direct experience with messenger RNA encapsulation/characterization/handling is preferred.
  • Experience with developing and optimizing formulations tailored for inhalation is advantageous.
  • Proficiency in analytical techniques (HPLC/UPLC, DLS, CD, zeta potential, UV-Vis and fluorescence spectrophotometry).
  • Demonstrated understanding and success in implementation of RNA-related analytics (Ribogreen, gel electrophoresis, capillary electrophoresis, etc.).
  • Experience in developing lyophilized formulations would be advantageous.
  • Desire to work in a fast-paced environment.
  • Excellent organizational and communication skills.
  • Strong analytical and problem-solving skills.
  • Works collaboratively within group as well as within interdisciplinary teams.
  • Desire to work in a fast-paced environment.

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