• , US

Company:  Confidential

Job Title: Research Associate

Job Number: 79868

Location: , US

Job Description

The In-Vitro Research Associate/Senior Research Associate is primarily focused on assay development and will play a critical role in the design, optimization, and implementation of in-vitro assays to support drug discovery and development. This position involves working collaboratively with cross-functional team members to develop and validate assays that assess the biological activity, efficacy, and safety of potential therapeutic compounds. This job description outlines the key responsibilities and qualifications for an In-Vitro Research Associate/Senior Research Associate focused on assay development. The role is critical in ensuring the success of drug discovery projects by providing reliable and robust in-vitro data to inform project decisions. This is a contract role at 30 hours per week.

Responsibilities

Key Responsibilities: 1. Assay Development and Optimization: – Design, develop, and optimize various in-vitro assays, including biochemical, cell-based, and high-throughput screening (HTS) assays. – Identify and implement the most appropriate assay formats and technologies (e.g., ELISA, fluorescence, luminescence, HTRF assays). – Troubleshoot and resolve technical issues related to assay performance and reliability. 2. Validation and Standardization: – Validate assay performance parameters such as sensitivity, specificity, accuracy, precision, and robustness. – Establish standard operating procedures (SOPs) and protocols for assay execution and data analysis. 3. Data Analysis and Interpretation: – Perform data analysis using appropriate statistical and computational tools. – Interpret and present assay results to multidisciplinary project teams, contributing to decision-making processes in drug discovery programs. – Maintain accurate and detailed laboratory records. 4. Collaboration and Communication: – Work closely with medicinal chemists, biologists, pharmacologists, and other research personnel to support the progression of drug candidates. – Communicate assay development progress, results, and challenges to internal and external stakeholders through written reports and oral presentations. 5. Innovation and Continuous Improvement: – Stay current with advances in assay technologies and methodologies. – Propose and implement innovative approaches to improve assay performance and throughput. 6. Compliance and Safety: – Ensure compliance with all relevant regulatory requirements, guidelines, and laboratory safety protocols. – Participate in laboratory inspections and audits from site and city officials as needed. – Is in possession of / has ability to test for the FDNY C-14 license.

Required Skills

Qualifications: Education: – Master’s degree with 2-4 years relevant experience, preferably in an industrial setting. – Alternatively, a Bachelor’s degree with at least 4 years of experience performing assay screening. Experience: – Demonstrated experience in developing and optimizing in-vitro assays. – Experience with high-throughput screening and automation technologies is highly desirable. – Knowledge of drug discovery and development processes. Technical Skills: – Proficiency in various assay techniques such as ELISA, fluorescence/luminescence-based assays, etc. – Strong data analysis skills, including familiarity with software tools like GraphPad Prism, Excel, and relevant statistical software. – Experience with electronic inventory systems (e.g. Quartzy) and maintaining an electronic lab notebook (ELN), e.g. Lab Archives, Benchling, etc. – Excellent command of Microsoft Suite. Soft Skills: – Excellent problem-solving skills and attention to detail. – Strong organizational and project management abilities. – Effective communication and interpersonal skills for collaborative work. Preferred Qualifications: – Experience with laboratory automation and liquid handling systems. – Familiarity with regulatory guidelines related to assay validation (e.g., FDA, EMA). – Experience in a pharmaceutical or biotechnology industry setting.

Application Deadline: 2024-07-08

 

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