Program/Project Lead – Gene Therapy

Job Title: Program/Project Lead – Gene Therapy

Job Number: 28023

Location: Cambridge, MA

Job Description

Dyno’s platform is expanding to support Capsid discovery across an array of therapeutic areas. As a Program lead, your role will be to plan and execute the capsid engineering strategy for a focus area such as the CNS, liver, muscle, kidney or eye, with the goal of discovering capsids with transformative potential for delivering gene therapies.

In the role of Program lead you will create scientific strategy by developing an in-depth understanding of Dyno’s platform workflows and defining new platform capabilities to support optimization of properties with specific relevance to the Program. This is a highly collaborative position in which you will coordinate execution of strategy by integrating across the many disciplines represented within Dyno, from molecular biology to machine learning.

Responsibilities

• Define capsid properties of value to gene therapy in your focus area
• Lead Partner-facing scientific interactions
• Specify Program milestones and manage timelines 
• Configure platform high-throughput screening workflows
• Design in vivo capsid selection assays tailored to overcome the physiological barriers of delivery to target organs
• Build translational validation assays relevant to therapeutic focus areas
• Design and manage animal studies 
• Analyze and interpret results throughout each round of screening, with an emphasis towards iteratively improving screening strategy
• Collaborate with a diverse team of wet-lab scientists, protein engineers, and computational scientists

Required Skills

Basic qualifications

• PhD in biology, biochemistry, biomedical engineering, or a related field
• Strong track record leading cross-functional projects 
• 3+ years working in a gene therapy field
• Expertise in molecular biology, vector design, mammalian tissues and disease models
• 5+ years hands-on wet lab experience

Preferred qualifications

• 2+ years post PhD experience
• Hands on experience using AAV capsids for gene delivery
• Expert level knowledge of organ physiology in CNS, liver, muscle, kidney or eye, or in other areas that present new opportunities for gene therapy
• Experience in protein engineering and/or computational analysis of high throughput data 
• Experience in preclinical development 
• Mentoring and managing experience