Casebia Therapeutics

Job Title: Process Development Engineering Associate

Job Number: 18630

Location: Cambridge, MA

Job Description

If you like a challenge, love to learn and want to be part of a team developing the next generation of gene editing biotherapeutics based on CRISPR/Cas9, we would like to hear from you.  Our ideal candidate will have hands-on technical experience with downstream process development for the manufacture of biologics and will have a solid understanding of bioprocess engineering principles. The position will be responsible for downstream purification of recombinant viruses and will be a key member of the team developing expression and purification strategies for novel gene editing/gene therapy vectors.

Responsibilities

  • Contribute to a smart, integrated development approach for definition of scalable viral vector processes and suitable control strategies  
  • Plan and perform experiments to develop purification process steps including chromatography (affinity, IEX, HIC, SEC, etc.) and filtration (depth filtration, UFDF, and sterile filtration)
  • Perform experiments to develop robust downstream unit operations, using DoE, multivariate analysis, and other statistical tools
  • Manufacture critical materials for developmental and preclinical testing
  • Participate in tech-transfer activities with CMOs

Required Skills

  • BS (3+ yrs.) or MS (1+ yrs.) in a relevant scientific discipline (e.g. Biological or Chemical Engineering, Biology, Virology) with experience in bioprocess development
  • Hands on experience with downstream processing of biologics – especially for viral vectors: adeno associated virus (AAV), lentivirus
  • Experience in bioprocess unit operations: centrifugation, depth filtration, chromatography (ion exchange, size exclusion, affinity), tangential flow filtration, and sterile filtration
  • Desire to take on new technology challenges and broaden technical skill set, including upstream bioreactor manufacture of viral vectors and/or product characterization/analysis
  • Application of advanced automation and statistical data analysis in development, including design of experiments (DoE) is a plus
  • Excellent verbal and written communication skills
  • Ability to work independently and effectively in team-oriented environment; driven and highly organized, attention to details

 

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