Company:  Confidential

Job Title: Principal/Sr. Scientist Pharmacology, Translational Sciences

Job Number: 23891

Location: 950 Winter Street Waltham, MA

Job Description

The Principal Scientist Pharmacology in the Translational Sciences group will report to the Executive Director of Research and be a key member of the team and will partner with internal team leaders and external partners to develop and implement research on Translational Read-Through-Inducing Drug (TRID) programs. The ideal candidate will have a fundamental understanding and strong perspective of genetics, functional translational read through, pharmacology and experience as a contributing member of several pharmacology programs, with minimal supervision, from research/discovery to candidate selection.

Responsibilities

– Provide strong scientific expertise and effective leadership to the discovery research efforts and team
members.
– Play a key role in determining the mechanism of action of lead molecules.
– Provide strategic insights for pharmacology programs in discovery through transition to development.
– Work closely with development team members, when needed, to propose and develop clinically
relevant biomarkers.
– Recommend, oversee and manage CRO(s), vendors and academic collaborators to ensure that all
studies are performed in a quality, timely and scientific manner.
– In collaboration with management and research/discovery team members design, manage and
interpret results of in vitro and in vivo studies to inform clinical development.
– Communicate results effectively through written reports and presentations with stakeholders.
– Maintain a command of relevant scientific literature.
– Ensure that the team maintains clear, detailed, and up-to-date records of research.
– Maintain an atmosphere that is open to sharing ideas and listening to the contributions of others.

Required Skills

– PhD in, Molecular Biology, Pharmacology, or related field required
– 6-8 years of industry experience in in vitro/in vivo pharmacology (experience working in a fast paced,
small biotech environment is essential).
– Experience developing cell-based models of human disease. Including, but not limited to primary cell
assays, iPSCs, CRISPR generated cells and organoids.
– Project leadership experience with successfully taking small molecules from early stage discovery to
development decisions.
– Extensive knowledge in functional translational read-through and pharmacology.
– Experience working with CROs is essential.
– Experience in developing robust biological assays and decision-enabling

 

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