Job Title: Principal Scientist, Platform Chemistry

Job Number: 24211

Location: Cambridge, MA

Job Description

We are seeking a highly motivated Senior Scientist to join our chemistry platform team.  The individual should have expertise in troubleshooting synthetic methodology and designing safe and scalable synthetic routes.


  • Drive the expansion of internal chemistry capability by developing and optimizing novel synthetic methodologies for stapled peptides.
  • Serve as scientific expert in process chemistry to develop safe and scalable routes to custom amino acids and APIs.
  • Strategically plan a robust material supply chain to support formulation, IND-enabling studies as well as clinical trial material while being compliant to good laboratory and manufacturing practices
  • Work cross-functionally to develop phase appropriate analytical and purification methods, impurity isolation, and identification.
  • Guide selection CROs/CMOs and manage external projects and CRO/CMO performance  to obtain compounds critical to achievement of corporate goals.
  • Broadly impact overall discovery chemistry by enhancing efficiency and throughput of reactions to produce next-generation cell-penetrating mini proteins.
  • Communicate with other teams to ensure optimal coordination and efficiency across R&D.

Required Skills

  • Ph.D. in Chemistry with 7+ years of industry based synthetic chemistry experience required.
  • Extensive knowledge of cutting-edge chiral synthetic methodology and catalysis.
  • Strong track-record of bringing innovative solutions to solve chemistry problems.
  • Experience in bringing drug candidates to first-in-human studies
  • Capacity to execute tasks independently to achieve company goals on an established timeline.
  • Knowledge of excellent communication, organizational, multi-tasking, and teamwork skills.
  • Enthusiastic and adaptive to work in a dynamic research environment.


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