Job Title: Principal Scientist, Cell Biology
Job Number: 32341
Key responsibilities and tasks will include but are not limited to:
Contribute to the development of NGS assays to benefit drug discovery and translational research
Generate NGS libraries and perform library QC upstream of sequencing
Develop and edit protocols and standard operating procedures
Support department and corporate goals in NGS.
Carry out NGS and epigenomics assays to support large collaborative initiatives
Effectively communicate results in a group setting
Maintain an accurate and complete laboratory notebook and other records, as needed
Assist with lab organization and compliance with lab safety protocols
Coordinate with the Bioinformatics group, internally and externally, to process sequence data
Comply with the federal and local lab regulatory requirements
Ph.D.or MS degree with 3 more years of professional experience in molecular biology, biotechnology, or cell biology
Demonstrated expertise in molecular biology techniques, including DNA/RNA extraction & purification, NGS library preparation & QC, PCR, qPCR, etc.
Hands-on experience with single-cell sequencing assays
Demonstrated experience in nucleic acid extraction from tissues as well as plasma and cells for NGS applications
Strong understanding of NGS technologies, with a track record of utilizing such assays in a research environment; A deep understanding of molecular biology and biochemical techniques relevant to assay development.
Familiarity with Illumina sequencing, and hands-on experience in the generation and QC of Illumina sequencing libraries
Experience with standard molecular biology tools e.g., PCR, qPCR, gel and capillary electrophoresis
Being Familiar with R/Python is a big plus
Strong analytical and troubleshooting skills demonstrated through examples of projects supported
Ability to use technical skills and good time management to perform work efficiently and meet project timelines
Excellent verbal and written communication skills with a particular emphasis on clear documentation of experiments and studies are essential, as is a willingness to collaborate cross-functionally in a fast-paced and dynamic environment.