Principal Scientist/Associate Director, LNP Formulations

Job Title: Principal Scientist/Associate Director, LNP Formulations

Job Number: 30192

Location: , 

Job Description

The LNP scientist to associated director will focus on developing our LNP formulation pipelines, including optimizing the assembly, purification, buffer exchange, and scale-up of LNP-mRNA as well as particle analysis.

Responsibilities

• Plan formulation technology, lab buildout
• Develop, optimize, and scale-up mRNA formulation methods and pipelines
• Develop and apply LNP-mRNA analytical & sample minimization methods
• Create data management system

Required Skills

• Persistence, determination, client- and team-first mindset
• Ph.D. degree in pharmaceutical science, drug formulations, nucleic acid chemistry, molecular biology, biomedical or chemical engineering, or a related field
• Lipid nanoparticle assembly: Precision Nanosystems platform, home-grown systems (e.g. pumps, tubing, junctions, dilution)
• Lipid chemistry, experience screening novel routes of administration, and liver de-targeting
• Deep knowledge of emerging nanoparticle chemistry, leading labs, and external collaborations
• Tangential flow filtration, ultrafiltration/diafiltration, crossflow at small and larger scales (e.g. AKTA Flux)
• Cell biology: cell line and primary cell culture maintenance, expansion, banking; transfection optimization
• Optimization through design of experiments and statistical modeling (e.g. JMP)
• Deep understanding and practical knowledge of the scientific method, selection of experimental controls
• High attention to detail including planning, executing, and documenting experiments
• Communication skills including protocol writing, working directly with clients, Power Point