1-617-500-6690 [email protected]
  • Full Time (Salaried)
  • ,

Company:  Confidential

Job Title: Principal Scientist/Associate Director, LNP Formulations

Job Number: 30192

Location:

Job Description

The LNP scientist to associated director will focus on developing our LNP formulation pipelines, including optimizing the assembly, purification, buffer exchange, and scale-up of LNP-mRNA as well as particle analysis.

Responsibilities

  • Plan formulation technology, lab buildout
  • Develop, optimize, and scale-up mRNA formulation methods and pipelines
  • Develop and apply LNP-mRNA analytical & sample minimization methods
  • Create data management system

Required Skills

  • Persistence, determination, client- and team-first mindset
  • Ph.D. degree in pharmaceutical science, drug formulations, nucleic acid chemistry, molecular biology, biomedical or chemical engineering, or a related field
  • Lipid nanoparticle assembly: Precision Nanosystems platform, home-grown systems (e.g. pumps, tubing, junctions, dilution)
  • Lipid chemistry, experience screening novel routes of administration, and liver de-targeting
  • Deep knowledge of emerging nanoparticle chemistry, leading labs, and external collaborations
  • Tangential flow filtration, ultrafiltration/diafiltration, crossflow at small and larger scales (e.g. AKTA Flux)
  • Cell biology: cell line and primary cell culture maintenance, expansion, banking; transfection optimization
  • Optimization through design of experiments and statistical modeling (e.g. JMP)
  • Deep understanding and practical knowledge of the scientific method, selection of experimental controls
  • High attention to detail including planning, executing, and documenting experiments
  • Communication skills including protocol writing, working directly with clients, Power Point

 

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