Tango Therapeutics

Job Title: Principal Scientist / Associate Director, Biochemistry

Job Number: 23048

Location: Cambridge, MA

Job Description

We are seeking a highly-skilled biophysics expert to work across multiple programs as an integral member of our biochemistry group. The successful candidate will have a minimum of five years’ experience in an industrial drug discovery setting characterizing enzymes and protein targets and utilizing biophysical methods to confirm and corroborate inhibitor affinity and mode of inhibition.  Expertise with Biacore technology is essential.  Experience in other biophysical techniques including Microscale Thermophoresis, DSF and ITC is important.  A strong working knowledge of HTS and hit triage is a plus. This candidate will work across multiple projects internally, as well as coordinate with CROs to perform biophysics experiments externally.  An appreciation of enzyme kinetics and thermodynamics and the flexibility to work on multiple targets is essential.

Responsibilities

  • Biophysical methods: Biacore, ITC, DSF, and MST
  • Coordinating with multiple CROs performing biophysical experiments and HTS
  • Familiarity with fluorescence spectroscopy, including FRET and FP assays
  • HTS experience and hit triage a plus
  • Data analysis, determining mode of inhibition and performing simulations to guide further experiments

Required Skills

  • PhD in Biochemistry or related field with a minimum of 5 years of industry experience
  • Post-doctoral experience with a strong publication record
  • Experience with small molecule targets
  • Strong attention to detail and the ability to handle multiple tasks
  • Ability to work in a cross-functional environment and a flexible 
team-oriented perspective
  • Strong interpersonal skills
  • Strong verbal and written communications skills
  • Candidates who are keen experimentalists, enthusiastic, creative and have a passion for drug discovery are encouraged to apply

 

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