Casebia Therapeutics

Job Title: Principal Research Associate, Molecular and Cellular Biology

Job Number: 22322

Location: Cambridge, MA

Job Description

Casebia Therapeutics is seeking a research associate/principal research associate (depending on experience) for our Ophthalmology group, based in Cambridge, MA. The successful candidate will help develop novel gene editing therapies and contribute to Casebia’s strategic research plans in ophthalmology. S/he will assist with discovery research projects through preclinical studies and help transfer work to CROs and service providers. We are seeking candidates who have experience with gene editing tools, preferably CRISPR/Cas9 or TALEN or ZINC Finger Nucleases, and/or experience with gene delivery of viral (e.g. AAV, Lentiviral) and/or non-viral (e.g. nanoparticle, liposome).


  • Assist in developing and implementing a preclinical research plan from discovery to IND/CTA filing
  •  Develop CRISPR/Cas9 gene editing tools
  •  Plan, develop and perform molecular biology and cellular biology experiments
  •  Record, analyze and present experimental data under the direction of the Research Scientist
  •  Maintain laboratory equipment and rooms, and organize research reagents

Required Skills

  • BS/MS in a relevant scientific discipline with 2-5 + years’ industry experience
  •  Direct experience with assays and technologies related to molecular biology, gene editing, and/or viral and non-viral DNA/RNA delivery methods
  • Strong skills in molecular biology specifically DNA cloning
  • Hands-on experience with cell culture and transient transfection
  • Knowledge of scientific principles and concepts
  • Familiarity with genome editing and inherited ophthalmic disorders is preferred
  • Excellent oral and written communication skills
  • Ability to work in a team-oriented environment but also be a self-starter, internally motivated, with the ability to work independently
  • Scientifically rigorous, highly organized, with significant attention to detail
  • High energy level, focus, a passion and sense of urgency for developing important new medicines for devastating diseases


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