Postdoctoral Scholar-Structural Biology in Protein Dynamics

Job Title: Postdoctoral Scholar-Structural Biology in Protein Dynamics

Job Number: 84510

Location: New York, US

Job Description

[Please click the Apply button for the link or email] in the Departments of Genetics and Genomic Sciences & Pharmacological Sciences at the Icahn School of Medicine at Mount Sinai (ISMMS) has an immediate opening for a Postdoctoral Research Scientist specializing in macromolecular cryo-EM and X-ray crystallography. The position focuses on investigating the structure-dynamics-function relationships of key molecules involved in Alzheimer’s disease and cancer. Our lab collaborates closely with the Mount Sinai Center for Transformative Disease Modeling to identify and study top molecular drivers as potential therapeutic targets. 

 

Position Summary:

The ideal candidate is expected to contribute to the investigation of the structure and dynamics of disease-related protein targets using single-particle cryo-EM, X-ray diffraction, and/or molecular simulations. You will also have the opportunity to participate in structure-assisted drug design in collaboration with computational scientists. This role offers the opportunity to join a multidisciplinary team dedicated to advancing time-resolved structural biology techniques to understand and manipulate the structure, function, and dynamics of drug targets.

 

What we provide:

– Wide choices of curated targets in the Alzheimer’s disease and cancer context.

– Access to state-of-the-art [Please click the Apply button for the link or email] and [Please click the Apply button for the link or email] facilities, as well as research partnership with [Please click the Apply button for the link or email].

– Collaborative and multidisciplinary environment, working closely with the [Please click the Apply button for the link or email] and computational scientists on structure-assisted drug design.

– Professional development opportunities, including authorship of research publications, presentations at national and international conferences, and mentorship roles with graduate and undergraduate students.

– Comprehensive training and skill development in advanced structural biology techniques and biophysical characterization methods.

– Competitive compensation package with comprehensive benefits, supporting your health, welfare, and financial well-being.

What you provide:

– Employ structural biology techniques to study and understand the structure, function, and dynamics of disease-related proteins and protein-ligand complexes.

– Publish research findings in peer-reviewed journals and present results at national and international conferences.

– Mentor graduate and undergraduate students.

– Contribute to grant proposals and progress reports.

 

Qualifications:

– Required:

  – Ph.D. in structural biology, biochemistry, biophysics, or related fields such as chemistry, physical chemistry, or biological structure research, completed within the last three years.

  – Proficiency in protein expression and purification in eukaryotic and prokaryotic systems.

  – Experience in single-particle cryo-EM or crystallization (or both), including structure determination and analysis of protein-ligand complexes.

  – Ability to interact effectively with research staff and work within a multidisciplinary team.

  – Good communication and presentation skills.

 

– Preferred:

  – Experience and strong knowledge in structure-based drug design.

  – Knowledge of and experience with Python coding.

  – Experience with other biophysical characterization methods.

  – A track record of productive and creative research, demonstrated by publications in peer-reviewed journals and presentations at scientific conferences.

 

Application Instructions:

Interested applicants are encouraged to send their cover letter, current curriculum vitae, list of publications, and names and contact information for at least three referees in one PDF file, when applying for this position. The cover letter should briefly describe their research interests and fit for this position. 

Application Deadline: 2024-11-15