Job Title: Postdoctoral positions in Structural Biology of Coronaviruses
Job Number: 69800
Location: Ames, Iowa, US
Two (2) postdoctoral positions are available in Dr. Yang Yang lab in the Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology at Iowa State University. We investigate the structures, functions, and regulation of various viral and bacterial RNA-protein complexes involved in RNA synthesis, processing, and signaling using cryo-electron microscopy (cryo-EM), single-molecule biophysics, protein-RNA biochemistry, and cell virological approaches. A particular emphasis in the lab’s research is placed on unravelling the molecular mechanism of coronavirus genome replication and transcription. The relevant recent publications include Liu et al, Science 2021; Liu et al, Nature 2019; Yang et al, Signal Transduction and Targeted Therapy 2021; Yang et al, PNAS 2021; Yang et al, Nature Communications 2021.
The positions are fully funded by NIH (NIAID and NIGMS) for at least three years (The initial appointment is for one year with renewal upon satisfactory performance evaluations).
About the cryo-EM facilities
The Iowa State has recently established a state-of-the-art cryo-EM facility through a large philanthropic gift from the Roy J. Carver Charitable Trust. The facility houses a Thermo Scientific Glacios Cryo-TEM equipped with a Gatan K3 Camera, joining an existing JEOL 2100 TEM equipped with Gatan OneView Camera.
In addition to the Glacios cryo-EM on campus, our lab also has ready access to a Thermo-Fisher Titan Krios 300 kV cryo-EM equipped with a Gatan BioQuantum K3 Imaging Filter and a Thermo Scientific Phase Plate, as well as a Thermo-Fisher Titan Krios 300 kV cryo-EM equipped with a Falcon 4i direct electron detector and a Selectris imaging filter.
We are looking for enthusiastic, highly self-motivated candidates with a Ph.D. or an equivalent degree in structural biology, virology, biochemistry, molecular biology, or a related field, and with strong laboratory skills in molecular cloning, protein expression/purification, and protein-nucleic acid biochemistry. Experience in coronavirus biology, cryo-electron microscopy (grid preparation and data processing), or X-ray crystallography (data processing, phase determination, model-building, and refinement) would be a plus.
Please submit your curriculum vitae, a brief statement of research experience and interests, and contact information of three references to Dr. Yang ([Please click the Apply button for the link or email]). Please use “Apply for postdoctoralposition” as the subject line in your email.
Application Deadline: 2024-05-12