Job Title: Postdoctoral Position: Regulation and Targeting of Pre-Leukemic Stem Cells
Job Number: 71535
Location: Bronx, New York, US
A full-time NIH-funded postdoctoral position is available in the Gritsman lab in the Departments of Medical Oncology and Cell Biology at Albert Einstein College of Medicine to study the regulation of self-renewal and differentiation by the PI3 kinase (PI3K)/AKT signaling pathway in the initiation and progression of myeloid malignancies, such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
The PI3K/AKT pathway plays an important role in the control of hematopoietic stem cell (HSC) homeostasis, and this pathway is also frequently activated in AML. The Gritsman lab recently discovered that the PI3K signaling pathway maintains the proper balance between HSC self-renewal and differentiation, at least in part by regulating autophagy in HSCs. By deleting three of the PI3K isoforms in hematopoietic cells, we generated a new mouse model of MDS, which we are using to better understand the mechanisms of MDS initiation, and for testing new therapeutic approaches for MDS: doi: 10.1126/sciadv.ade8222. We are also studying interactions between HSCs and pre-leukemic cells with the bone marrow microenvironment. Please join us if you want to contribute to this exciting research effort!
Candidates must have a PhD degree, and proficiency in both molecular biology and cell biology techniques. Experience with mouse models of disease, especially mouse models of hematopoiesis or leukemia, is strongly favored. Experience with flow cytometry, cell culture, and RNA sequencing is preferred.
Please send a CV, brief cover letter summarizing your research experience and future career goals, and contact information of three references.
Application Deadline: 2024-04-30