Postdoctoral position in Tumor and System Immunology (Krummel/Combes labs)

Job Title: Postdoctoral position in Tumor and System Immunology (Krummel/Combes labs)

Job Number: 63525

Location: San Francisco, US

Job Description

The Combes lab and the Krummel lab are searching for a postdoctoral fellow who is highly creative, motivated, and collaborative to lead a unique cross-disciplinary project at the forefront of tumor immunology, human immunology, and system immunology.

Cancer immunotherapy has revolutionized cancer care by acting directly on the tumor microenvironment and re-engaging the anti-tumor immune response. However, most patients do not derive clinical benefit, and it is very variable by tumor type. In our labs we focus on understanding why tumors don’t respond to existing Immunotherapies by understanding the spectrum of the Immune System in those tumors ([Please click the Apply button for the link or email]). Using a combination of multiparametric flow cytometry and new generation sequencing approaches Dr Combes and Krummel recently identified that solids tumors can be classified into 12 immune states or immune archetypes thar are spanning the tissue of origin but have strong association with patient survival ([Please click the Apply button for the link or email]). The successful candidate will work with Drs Combes and Krummel to dissect the cellular networks and gene programs underlying those archetypes and their relationship with cancer progression and drug resistance.  This project is possible thanks a unique cohort of human samples collected across a variety of cancer, and tissues with single-cell multiOMCIS data. This position gives the opportunity to work with a cross-disciplinary team composed of computational scientists, clinicians, and immunologists.

The Combes lab and the Krummel lab are both part of the Department of Pathology at UCSF and core members of the [Please click the Apply button for the link or email]. This is a first-in-class program at UCSF that utilizes state-of-the-art technologies, infrastructure, and a unique data-sharing model to support a community of researchers and clinicians in finding solutions together. By restructuring traditional research, we create opportunities for cross-fertilization of ideas, discoveries, and insights.

Mentoring is an essential aspect of this position, and we place great emphasis on helping the successful candidate achieve their career goals. This includes developing a mentoring plan that evaluates the needs and goals of each postdoctoral researcher based on their background, interests, and needs, and identifying activities necessary to achieve them. There will be opportunities to mentor trainees, including research associates and graduate students. UCSF provides several resources that support career development, such as workshops on preparing K99 awards and other fellowships.

Required Qualifications:

•   MD/PhD, PhD, or MD in immunology or a related field
•   Experience in immunological assays (e.g., cellular assays, flow cytometry, western blots, ELISA, animal work, single-cell sequencing)
• Ability to work independently.
•  Creativity and thinking outside the box.
• Collaborative mindset
• Motivation to utilize new technologies and explore novel concepts.
• Self-motivation and enthusiasm for the research project
• Attention to details.
•  Strong work ethics
• Excellent communication skills

Preferred Qualification:

A desirable set of expertise includes a combination of some of the listed areas:

• Experience in the analysis of large sequencing datasets.
  Experience In tumor immunology and human immunology
• Expertise in single-cell sequencing (e.g. single cell transcriptome, repertoire, ATAC-sequencing, library preparation)
• Expertise in bioinformatics (e.g. analysis of large genomics and/or proteomics datasets, R, Python, Bash).

Required Application Materials:

To Apply please contact [Please click the Apply button for the link or email] with the following materials:

• An updated CV and publication list
•  A short statement describing why you are interested in our lab, your past research experience, future research interest, and career goals (≤1 page)
• Contact information for 2-3 references (will not be contacted without your explicit permission

Application Deadline: 2024-01-10