Postdoctoral Fellowship in Genetically Encoded Sensors and Tools

Job Title: Postdoctoral Fellowship in Genetically Encoded Sensors and Tools

Job Number: 60115

Location: San Diego, US

Job Description

Dr. Cracan’ lab is developing novel methodologies to enable modulation of the cellular redox environment with spatiotemporal precision. The methodology is based on native and engineered enzymes that are amendable to targeting to different cellular compartments. Our tools will lead to a better understanding of the role of redox imbalance in cancer, neurodegeneration and aging and hold therapeutic promise for reversing metabolic imbalances. Our lab is highly collaborative with local groups at SBP, TSRI, UCSD as well as other laboratories in the US and elsewhere. For more information, please visit https://cracanlab.com/.

We are currently looking for a collaborative, self-motivated Postdoctoral Associate to work in the laboratory of Dr. Valentin Cracan at the Scintillon Institute situated in the academic cluster of La Jolla/San Diego, CA. The Postdoctoral Associate will have the opportunity to define compartmentalization of redox metabolism in normal physiology and disease, including aging-associated metabolic changes in different cellular and organismal backgrounds. This is an excellent opportunity for someone who is interested in the development of novel genetically encoded sensors and tools for studying organelle redox biology with a special focus on redox coenzymes NAD+ and NADP+. Techniques that are routinely used in the laboratory include protein production in different overexpression systems, protein biochemical and biophysical characterization, protein engineering, mammalian cell culture, various high-throughput biochemical assays, high-content imaging and LC-MS/GC-MS based metabolomics.

Pristine coastline, fabulous beaches, year-round sunshine and mild temperatures make San Diego, CA a fantastic place to work and live. In addition, San Diego is situated not far away from Los Angeles, CA and many other outstanding destinations along the coastline.

Qualifications:

·       Highly motivated individuals with a PhD in structural biology, biochemistry, enzymology, chemical biology or related area with a track record of scientific accomplishments as exemplified by first author scientific publications are encouraged to apply. Preference will be given to recently graduated candidates with strong career motivation.

·       Prior experience in any aspect of protein expression/purification, protein design, directed evolution, cellular bioenergetics and redox biology is preferred.

·       Background in fluorescent protein biosensors, chemogenetics or optogenetics would be ideal but not required.

Postdoctoral Associate will be expected to contribute to ongoing projects and expand novel independent research projects in a collaborative research environment. Responsibilities include experimental designs and execution, data analysis, team and conference presentation, literature reviews and paper writing. Competitive stipend and a generous benefits package commensurate with experience will be provided according to NIH guidelines.

Application Instructions:

To apply, please send the following materials as a single PDF file to Dr. Valentin Cracan ([Please click the Apply button for the link or email]):

1). Cover letter indicating current research interests.

2). Your curriculum vitae with names and contact information for 3 references.

Application Deadline: 2023-10-28