Company:  Confidential

Job Title: Postdoctoral fellow to study aging and diapause in the African killifish

Job Number: 75266

Location: Sab Fraancisco, US

Job Description

Multiple fully funded postdoctoral positions are available in the Singh Lab at the University of California, San Francisco ( to study vertebrate aging and embryonic diapause in African killifish. Our lab uses interdisciplinary approaches to study the mechanisms of age associated functional decline and extreme phenotypes, using African killifish as a model system. These fish have evolved extraordinary adaptations to survive in their extreme habitat, including a state of ‘suspended animation’ called diapause and a compressed lifespan of ~6 months. These phenotypes make them a rapid and unique vertebrate model to study diapause, aging, and age-related diseases. Our lab leverages the unique biology of African killifish combined with cross-species comparative genomics to target conserved aspects of aging and disease.

Current projects involve researching the genomic underpinnings of metabolism during suspended animation and aging in killifish, the genomic basis of longevity differences across species, and conserved mechanisms of cognitive decline and brain aging. Our lab uses interdisciplinary approaches, including single-cell, bulk, and spatial ‘omics’ technologies, CRISPR-based perturbations, computational modeling, and machine learning. The development of new experimental, computational, and statistical approaches is an integral part of our work. This position offers outstanding opportunities to develop independent research projects in aging, evolutionary/developmental biology, and bioinformatics. We are looking for postdocs with computational, experimental, or interdisciplinary backgrounds.

Successful candidates for postdoctoral positions are expected to have a Ph.D. in a relevant field with a strong publication record. They should be ambitious, highly motivated, collaborative, and able to conduct independent research. Our laboratory fosters a dynamic and collaborative environment and is a part of the wider communities UCSF offers, including the Bakar Aging Research Institute ([Please click the Apply button for the link or email]) and the Bakar Computational Health Sciences Institute ([Please click the Apply button for the link or email]).

Required Qualifications

  • We are looking for candidates with backgrounds in both computational and/or experimental biology. The ideal candidate should have a PhD or MD/PhD in genetics, developmental biology, molecular biology, genomics, computational biology, biological engineering, or a related field.
  • Strong track record of publications with demonstrated aptitude to perform experimental protocols, procedures, and genomic data analysis.
  • Excellent communication and organization skills.
  • Ability to work independently as well as as part of a team.
  • Previous work with animal models, specifically aquatic models such as zebrafish, is a plus.

Desired Qualifications

For the experimental postdoc position

  • Strong skills in molecular and developmental biology such as Cloning, PCR, DNA/RNA extraction, live imaging, confocal/time-lapse microscopy, microinjection, transgenesis, IHC, etc.
  • Experience with CRISPR-based approaches for genome manipulation.
  • Generation of single-cell, spatial, or multi-omics libraries.

For the computational postdoc position

  • Expertise in R and/or Python to analyze single-cell, multi-ome, or spatial genomic datasets in a Unix/Linux-based HPC or cloud environment.
  • Knowledge of statistical methods for data analysis, preferably with applications to high-throughput genomics.
  • Familiarity with machine learning and deep learning techniques for biological data analysis, including proficiency in applying these methods to genomic, proteomic, or imaging datasets.

Candidates with an interdisciplinary background in both computational and experimental biology are highly encouraged to apply.

If interested, please send a CV with the contact information of three references and a cover letter describing your research background, interests, and future plans to [Please click the Apply button for the link or email].

We will consider applications on a rolling basis until all positions are filled.

UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status.

Application Deadline: 2024-07-31


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