Company:  Confidential

Job Title: Postdoctoral Fellow – Cell cycle control of cellular metabolism

Job Number: 80510

Location: Piscataway, New Jersey, US

Job Description

Cell cycle phase-specific control of cellular metabolism in health and disease

Exploiting metabolic vulnerabilities in cancer

The Valvezan lab studies how metabolic networks are coordinated to promote cell growth, and how to leverage that understanding to exploit metabolic dependencies in cancer. We recently discovered that the activity of the master metabolic regulator Mechanistic Target of Rapamycin Complex 1 (mTORC1), oscillates throughout the cell cycle with important functional consequences for cell growth and proliferation.

 We seek a postdoctoral fellow to study how metabolism is differentially regulated throughout the cell cycle, and whether there are cell cycle phase-specific metabolic vulnerabilities that can be exploited in cancer. 

We also discovered a targetable metabolic vulnerability that is induced downstream of mTORC1 in cancer, and can be exploited using clinically approved therapeutics to selectively kill cancer cells that have uncontrolled mTORC1 activation. We seek a postdoctoral fellow to determine the full translational potential of this potent vulnerability in human cancers.

The postdoctoral fellow will work at the interface of basic and translational science, combining genetic, pharmacological and molecular biology/biochemistry approaches with the latest metabolomics, metabolic flux analysis, and expression profiling assays in cultured cells and mouse tumor models to gain a comprehensive understanding of how the cell cycle remodels cellular metabolism and how to leverage these insights for therapeutic benefit.

To apply please email your CV/resume and a Cover Letter containing a brief description of your background, research interests, and career goals to Dr. Alexander Valvezan.

Application Deadline: 2024-12-01


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