Postdoctoral Fellow- Cancer Evolution, Lineage Plasticity, Drug Resistance

Job Title: Postdoctoral Fellow- Cancer Evolution, Lineage Plasticity, Drug Resistance

Job Number: 94773

Location: New York, US

Job Description

Postdoctoral Fellow in Cancer Evolution, Lineage Plasticity, and Drug Resistance

Position Description:
The Sen Lab is seeking a highly motivated and enthusiastic Ph.D. or MD/Ph.D. scientist to join our team as a postdoctoral research fellow. The lab focuses on understanding the mechanisms of phenotypic plasticity, therapeutic resistance, and immune escape mechanisms in lung cancer. This position is supported by a newly funded NIH grant.

The research will involve high-throughput functional genomics using CRISPR-based screening, lineage tracing, and in vivo models to elucidate mechanisms underlying tumor evolution and drug resistance. The candidate will have access to state-of-the-art technologies and work in a highly collaborative, interdisciplinary environment.

The Sen Lab focuses on the development of new treatment paradigms for clinically relevant molecular subsets of lung cancer, the leading cause of cancer mortality. The Sen Lab takes an interdisciplinary approach to studying the basic mechanisms and biological principles of tumor pathogenesis with a focus on lung cancer. We aim to elucidate the fundamental principles of cancer initiation, progression, and therapeutic response and resistance and to translate these findings to improve patient outcomes. The overall goal of this research program—spanning basic mechanistic discoveries, application of high-throughput technologies, validation in cancer-relevant mouse models, and translation platforms—is to understand the fundamental principles driving tumor progression, including both cancer cell-intrinsic signaling and contributions from the tumor microenvironment, to improve therapy and survival outcomes in lung cancer patients.

What You Will Do:

• Conduct and design independent research projects
• Perform CRISPR/Cas9-based genetic screens, epigenetic and transcriptomic analyses
• Utilize animal models to investigate lung cancer progression and resistance mechanisms
• Analyze next-generation sequencing and epigenomic data
• Write scientific manuscripts describing research findings
• Attend national and international meetings to present research findings, learn about the latest advances in the field, and develop a scientific network
• Apply for fellowships and grants
• Mentor junior scientists

Qualifications:

• Ph.D. or MD/Ph.D. in molecular biology, cancer biology, genetics, or a related field
• Strong expertise in cell culture, gene editing (CRISPR-based approaches), and molecular biology techniques
• Experience with ATAC-seq, CHIP-seq, RNA-seq, and bioinformatics analyses
• Mandatory experience working with animal models of cancer
• Strong publication record, including at least two publication outputs in the last three years, with the applicant as the principal author of at least one publication
• Self-motivation and a curiosity-driven mindset
• Prior postdoctoral experience is not required

Application Requirements:

• CV, including a summary of work experience, publication activity, involvement in research grants, etc.
• Cover letter describing your motivation and previous experience
• Contact information for three references

Application deadline: 30th April 2025
Tentative Start date: July 2025 or by negotiation

Interested candidates should send their application as a single PDF file to [Please click the Apply button for the link or email]

Application Deadline: 2025-04-30