Company:  Confidential

Job Title: Postdoc to develop tools to image and manipulate cancer cell chromosomes.

Job Number: 72172

Location: San Francisco, US

Job Description

The Wittmann Lab at UCSF is seeking a highly motivated and talented Postdoctoral Researcher to join our team. The successful candidate will take charge of an innovative project to develop a molecular and imaging toolkit to observe and manipulate chromosome segregation dynamics with high spatial and temporal accuracy in three-dimensional model and patient-derived cancer organoids. Complex tumors are heterogenous assemblies of cancer cells, which contributes to aggressiveness, metastatic potential, and drug resistance. In contrast to normal cells in which chromosome segregation is tightly controlled to maintain a diploid chromosome set, cancer cells are frequently aneuploid. Indeed, abnormal gains or losses of chromosomes are amongst the most common characteristics of cancer cells with nearly all solid cancers exhibiting some type of aneuploidy. A high degree of tumor aneuploidy also correlates with poor clinical outcomes. Although this strong correlation between aneuploidy and cancer is well known, causal relationships are incompletely understood. You will use genome editing, optogenetics and advanced light microscopy to develop methods to locally manipulate chromosome segregation as well as to enable “live karyotyping” in cancer organoids. A strong background in mammalian cell biology and excellent experimental skills including molecular biology and genome editing approaches are a must. Knowledge of quantitative optical microscopy and image analysis using machine learning approaches is desirable. Excellent communication skills, both written and verbal and the ability to work independently and as part of a collaborative research team are expected.

The position is for a minimum of 2 years and the appointment may be extended contingent on funding and satisfactory performance. UCSF offers a stimulating scientific environment in one of the nation’s foremost biomedical research universities. Resources and current minimum salary scales for UCSF postdocs can be found at: The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

Please send CV, a statement of research experience and career goals, and contact information for 2-3 letters of reference (name and email address is sufficient).

Application Deadline: 2024-03-31


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