Company:  Confidential

Job Title: Postdoc Position in Fibroblast Biology

Job Number: 81351

Location: Dallas, US

Job Description

With over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern Medical Center is
committed to excellence, innovation, teamwork, and compassion. As a world-renowned medical and research center, we strive to provide the best possible care, resources, and benefits for our valued patients and employees. With over 20,000 employees, we are committed to continuing our growth with the best professionals in the healthcare industry. We invite you to be a part of the UT Southwestern team where you’ll discover teamwork, professionalism, and consistent opportunities for growth. UT Southwestern provides an outstanding and highly interactive scientific environment for research. In 2021, Nature Index ranked UT Southwestern as the No.1 healthcare institution globally in biomedical sciences. Among UT Southwestern’s faculty, there are six Nobel Prize recipients since 1985, 26 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, and 14 HHMI Investigators. UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community.

A postdoc position is available in the laboratory of Dr. Huocong Huang at UT Southwestern to study fibroblasts in cancer. We will employ in vivo models, mouse genetics, lineage tracing techniques, single-cell multiomics and spatial transcriptomics to understand the biology of fibroblast progenitors and fibroblasts. Our ultimate goal is to develop novel therapeutic strategies that can specifically target fibroblasts in the settings of cancer and other fibrotic diseases.

Dr. Huang is a tenure-track Assistant Professor in the Department of Surgery and Immunology at UT Southwestern. He received his Ph.D. in Biochemistry and Molecular Biology from University of Nebraska Medical Center and postdoctoral training at UT Southwestern. His postdoctoral research studied the function of cancer-associated fibroblasts (CAFs) and extracellular matrix in pancreatic ductal adenocarcinoma. His laboratory is the first group that reports the origin and function of a unique subtype of CAFs called antigen-presenting CAFs (apCAFs). Recent corresponding author publications from the Huang lab include Cancer Cell. 2024 PMID: 38670089, Cancer Cell. 2022 PMID: 35523176 (cited>230 times, highlighted by Cancer Cell and Cancer Discovery).

Prospective postdocs will have the opportunity to work on multiple promising research directions:
• Understand the immune-regulating mechanisms of fibroblasts
• Identify novel signaling pathways that reverse the cell fate of CAFs
• Develop novel therapeutic strategies that target CAFs in primary tumor and metastasis

Candidates must hold a recent Ph.D. or M.D., Ph. D degree. Experience in cancer biology,
immunology, molecular biology, developmental biology and bioinformatics resulting in publications in high-profile journals is preferred. Information on our postdoctoral training program, benefits, and a virtual tour can be found at

Interested individuals should email a CV, statement of interests, and a list of three references to:

Huocong Huang, M.D., Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd. Dallas, TX 75390
[Please click the Apply button for the link or email]

Application Deadline: 2025-01-03


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