Post-Doctoral Fellowship – Glycoconjugate Vaccines

Job Title: Post-Doctoral Fellowship – Glycoconjugate Vaccines

Job Number: 78074

Location: Silver Spring, US

Job Description

A research opportunity is currently available in the Office of Vaccines Research and Review (OVRR), at the Center for Biologics Evaluation and Research (CBER), Food

and Drug Administration (FDA) in Silver Spring, Maryland. This research opportunity will be within the Laboratory of Bacterial Polysaccharides with the goal of using recombinant technologies, metabolic engineering and/ synthetic biology as tools to improve the understanding of glycoconjugate vaccine synthesis and immunology. The selected participant will receive mentoring on fulfilling the project, which will also include collaboration with investigators within and external to the FDA. The participant will be studying Glycoengineered Outer Membrane Vesicles (geOMV) as an alternative platform to generate glycoconjugate vaccines that target encapsulated pathogens. The participant will generate a prototype expression system to reconstitute bacterial polysaccharides (e.g. capsule, O-antigen) in Escherichia coli, and test and evaluate the immune response of the purified geOMV.

Qualifications

The qualified candidate should have received a Doctoral degree in Biochemistry, Microbiology, Immunology, or related field. Degree must have been received within five years of the appointment start date. Applicants must have resided in the USA for 3 of the last 5 years.

Preferred skills/knowledge:

• Molecular biology (e.g. molecular cloning)

• Biochemistry (e.g. recombinant protein expression and purification, PAGE/Western blot protein analysis)

• Tissue culture

• Mass spectrometry

• Immunology

• Strong written and oral communication skills

The following papers provide examples of the research project:

1. Haurat, M.F. et al. Biol Chem. 2015. doi: 10.1515/hsz-2014-0183

2. Elhenawy, W. et al. MBio. 2016. doi: 10.1128/mBio.00940-16

3. Price, N. L. et al. Sci Rep. 2016. doi: 10.1038/srep24931

4.  Sartorio, M.G. et al. Annu Rev Microbiol 2021. doi: 10.1146/annurev-micro-052821-031444

Application Deadline: 2024-10-01