1-617-500-6690 [email protected]

Company:  Confidential

Job Title: Director, Oligonucleotide Synthesis

Job Number: 30216

Location: Waltham, MA

Job Description

The Director of Oligonucleotide Synthesis will report to the Head of Platform Development and is responsible for leading oligo design, manufacturing and purification.  S/he will manage internal and external oligo synthesis, analytics, and characterization of ASO and siRNA chemistries. The candidate will be a subject matter expert in the understanding of testing, scale-up and cGMP manufacturing of nucleic acid drugs with a comprehensive understanding of oligo delivery and formulations.  S/he will collaborate closely with additional chemistry, biology, and research teams, supporting all stages of preclinical therapeutic development.  The candidate will use creative and proactive problem-solving strategies to progress oligo design and development in support of their therapeutic pipeline.  S/he will act as an effective technical expert and work in a collaborative, constructive and mission-oriented focus for improving the lives of patients.

Responsibilities

  • Lead oligo design, manufacturing and purification
  • Manage internal and external oligo synthesis, analytics, and characterization of ASO and siRNA chemistries
  • Collaborate with additional chemistry, biology, and research teams, supporting all stages of preclinical therapeutic development
  • Scale-up manufacturing
  • Select and manage CROs
  • Act as an effective technical expert for oligo design and development

Required Skills

  • PhD in Chemistry, Biochemistry, or related discipline; with 8-10 years of relevant experience in drug discovery and development.
  • Strong practical knowledge of design, synthesis, and purification of nucleic acids.
  • Experience in scale-up manufacturing.
  • Excellent project, time management, and problem-solving skills.
  • Proven leadership and interpersonal skills, including ability to work across functional lines.
  • Ability to select and manage third-party vendors and collaborators, communicate technical information and work with all levels and functions within the Company.
  • Excellent written and verbal communication skills, including making effective and compelling presentations in both large and small groups and communicating complex scientific and nonscientific issues to program teams.
  • Ability to critically evaluate, summarize, interpret data.
  • Understand published scientific literature outside of his/her immediate area of expertise and appropriately apply this understanding to company aspects
  • Prepare manuscripts and other documents for publication and/or regulatory submission

 

Apply for job

To apply for this job please visit k7y.pl.