LifeMine Therapeutics

Job Title: Director, Discovery Fermentation

Job Number: 22431

Location: Cambridge, MA

Job Description

We are seeking a fermentation scientist with expertise in the fermentation of filamentous fungi from microtiter-plate to bench-scale. This role will be instrumental in optimizing our early stage fermentation process by implementing innovative high-throughput fermentation strategies to induce and optimize secondary metabolite production in filamentous fungi.


  • Coordinate and oversee the simultaneous small scale fermentation of multiple native and genetically engineered fungal strains.
  • Develop innovative high throughput fermentation strategies for unique strains of filamentous fungi.
  • Proactively evaluate and implement new technologies into the company’s genomically-enabled drug discovery pipeline.
  • Analyze and act upon complex data sets requiring sophisticated decision-making.
  • Work closely with the microbiology team to maintain alignment with the overall R&D objectives of the Company.
  • Actively collaborate with LifeMine’s Genomic, Synthetic Biology, Natural Product Chemistry, Mass Spectroscopy, and Medicinal Chemistry functions to design and execute mission-critical experiments.
  • Establish processes for detailed, accurate, auditable record keeping and data storage.
  • Create a high-performance, rewarding and safe working environment for the Fermentation & Microbiology Group.

Required Skills

  • M.S. or Ph.D. in Mycology, Microbiology or related field.
  • 10+ years of industry experience in small scale fermentation of filamentous fungi.
  • Expert knowledge in the handling and fermentation of diverse fungal species.
  • Deep experience in the implementation of state-of-the-art techniques to induce and maximize production of secondary metabolites.
  • Strong project management skills with the ability to deliver results on schedule in a fast-paced entrepreneurial environment.
  • Demonstrated experience building, managing, and developing a productive and innovative team.
  • A personality of risk-taking, positivity, leadership, adaptability, adventurousness, and excitement to build a pioneering company and work in a dynamic, goal- and performance-oriented team environment.
  • A solid understanding of fungal molecular genetics and the regulation of secondary metabolite production in filamentous fungi is a plus.


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