Computational Biology Postdoctoral Fellow

Job Title: Computational Biology Postdoctoral Fellow

Job Number: 69519

Location: Yale School of Medicine, New Haven, CT, US

Job Description

Computationally-Focused Postdoctoral Fellow or Associate Research Scientist Interested in Cancer Immunotherapy and Immunogenomics – The Braun Lab

The Braun Lab (Yale Center of Molecular and Cellular Oncology / Yale Cancer Center / Yale School of Medicine; [Please click the Apply button for the link or email]) is seeking a highly motivated, computationally-focused postdoctoral fellow or associate research scientist interested in cancer immunotherapy and immunogenomics to join our translational research team.

Our laboratory aims to understand the key determinants of effective anti-tumor immunity, utilizing high-dimensional analytic tools and patient-derived models to study human tumors. We have focused our efforts on renal cell carcinoma (kidney cancer), and our work has helped to elucidate genetic and immunologic features that impact response to immune checkpoint inhibitors (Braun, Nature Medicine, 2020) and to define the immunologic changes that occur with progression to advanced disease (Braun, Cancer Cell, 2021). We now aim to understand the antigenic and immune microenvironmental features that determine why kidney cancers respond or a resistant to current immunotherapies, and to create patient-derived pre-clinical models to aid the development of novel immunotherapy approaches in this disease (Braun, Nature Reviews Clinical Oncology, 2021).

Candidates with MD, PhD, or MD/PhD degrees and expertise/experience in bioinformatics, computational biology, computer science, mathematics, physics, and/or statistics are encouraged to apply. Successful candidates will be expected to work collaboratively with other experimental postdoctoral fellows, computational biologists, graduate students, and other trainees in the laboratory. High priority will be given to candidates with prior experience in bulk genomic/transcriptomic analysis (including data pre-processing), single-cell transcriptomic analysis, and machine learning methods.

Interested applicants should send a cover letter (describing prior research and future goals, AND listing contact information for 3 references) and a CV to [Please click the Apply button for the link or email] .

The Braun Lab uses reverse translation to understand human tumor immunology, with the goal of improving immunotherapies for patients with cancer. We are located at Yale University, an internationally-renowned research university located in the historic city of New Haven, Connecticut. Yale has long been recognized as an outstanding environment for nurturing young scientists, with postdoctoral researchers being an integral part of the discovery process.

Application Deadline: 2024-05-08