Biochemistry and Structural Biology of RNA-protein Complexes

Company:  Confidential

Job Title: Biochemistry and Structural Biology of RNA-protein Complexes

Job Number: 100373

Location: Dallas, TX, US

Job Description

Biochemistry and Structural Biology of RNA-protein Complexes

A postdoctoral research position is available in the laboratory of[Please click the Apply button for the link or email], in the Department of[Please click the Apply button for the link or email] at the[Please click the Apply button for the link or email] in[Please click the Apply button for the link or email], to study the mechanisms underlying RNA-protein complexes important for gene regulation. Our[Please click the Apply button for the link or email] works on exciting projects dissecting the rules that govern RNA-protein recognition. We investigate how specific RNA-protein interactions contribute to proper gene regulation. More specifically, we investigate the core and regulatory mechanisms that govern RNA processing (eg. microRNA and small RNA maturation via endonucleases), modification (eg. methylation), and folding (eg. RNA helicases) that impact the RNA function in the cell. The RNA-protein complexes we study are relevant for normal development as well as diseases. As we unravel how dysregulated RNA-protein complexes derail gene expression and cause cancer, we use our mechanistic understanding to identify novel therapeutic avenues.

 

To study how proteins and RNAs recognize each other, we use biochemical and biophysical methods. Postdoctoral scholars will have opportunities to learn the newest methods in protein and nucleic acid biochemistry and biophysics, in addition to working in an exciting, fast-evolving field of RNA biology and therapeutics. We use various approaches, including cryo-electron microscopy (cryo-EM), X-ray crystallography, NMR spectroscopy, molecular biology, nucleic acid and protein biochemistry, genomics with next-generation sequencing, high-throughput screening for drug discovery, and cancer cell biology. The postdoctoral fellow will have ready access to the top-of-the-line equipment and resources necessary for the above approaches. For cryo-EM, we have ready access to four microscopes on our campus: two Titan Krios, one Glacios, and one Talos Arctica. Information on our postdoctoral training program, benefits, and a virtual tour can be found on the UTSW [Please click the Apply button for the link or email].

Candidates must hold a Ph.D. or an M.D. degree. Experience in biochemistry and structural biology leading to publication in peer-reviewed journals is recommended.

Interested individuals should email the PI (Yunsun Nam) a CV (with publications and contact information for 3 references listed) and a one-page cover letter that contains: ● A summary of your past research experiences and accomplishments. ● A statement of interest in Nam Lab and why you could be a great fit. ● Your goals for your postdoctoral training period. ● Potential start date. 

Yunsun Nam, Ph.D.
Department of Biochemistry
UT Southwestern Medical Center
[Please click the Apply button for the link or email]
Lab Website:[Please click the Apply button for the link or email]
[Please click the Apply button for the link or email]

 

UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status. 

Application Deadline: 2025-08-19

 

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