Associate/Sr. Associate Scientist/Engineer, Oligonucleotide Process Chemistry

Job Title: Associate/Sr. Associate Scientist/Engineer, Oligonucleotide Process Chemistry

Job Number: 35672

Location: , 

Job Description

Seeking a motivated Associate or Senior Associate Scientist/Engineer to support guide RNA synthesis. This hands-on role involves executing experiments to produce high-purity long guide RNAs, including synthesis, deprotection, purification, and enzymatic ligation. The position requires working in a well-equipped chemistry lab, presenting data in team meetings, and collaborating across functions to advance programs toward clinical development.

Responsibilities

• Perform solid-phase synthesis, deprotection, purification, and delivery of guide RNAs for in vitro and in vivo studies.
• Work independently after initial training, using equipment such as RNA synthesizers, chromatography systems, and analytical instruments.
• Support high-throughput guide RNA production for various programs.
• Review scientific protocols to enhance productivity and RNA synthesis quality.
• Present experimental data in internal team meetings.
• Troubleshoot and maintain lab equipment to ensure functionality.
• Plan and execute experiments in collaboration with the manager.
• Ensure safe laboratory practices and maintain a secure working environment.
• Keep detailed records in an electronic notebook and project reports.
• Stay engaged and adaptable in a dynamic, fast-paced environment.

Required Skills

• Bachelor’s degree (0-4+ years) or Master’s degree (0-2+ years) in chemistry or a related field.
• Experience with RNA synthesis, chemical deprotection, and oligonucleotide purification is a plus.
• Familiarity with analytical techniques such as UPLC, LC-MS, and UV-Vis is preferred.
• Self-motivated, proactive, and team-oriented with a problem-solving mindset.
• Organized, detail-oriented, and eager to learn and adapt.