Company: Confidential
Job Title: Associate/Sr. Associate Scientist/Engineer, Oligonucleotide Process Chemistry
Job Number: 89533
Location: , US
Job Description
Seeking a motivated Associate or Senior Associate Scientist/Engineer to support guide RNA synthesis. This hands-on role involves executing experiments to produce high-purity long guide RNAs, including synthesis, deprotection, purification, and enzymatic ligation. The position requires working in a well-equipped chemistry lab, presenting data in team meetings, and collaborating across functions to advance programs toward clinical development.
Responsibilities
* Perform solid-phase synthesis, deprotection, purification, and delivery of guide RNAs for in vitro and in vivo studies. * Work independently after initial training, using equipment such as RNA synthesizers, chromatography systems, and analytical instruments. * Support high-throughput guide RNA production for various programs. * Review scientific protocols to enhance productivity and RNA synthesis quality. * Present experimental data in internal team meetings. * Troubleshoot and maintain lab equipment to ensure functionality. * Plan and execute experiments in collaboration with the manager. * Ensure safe laboratory practices and maintain a secure working environment. * Keep detailed records in an electronic notebook and project reports. * Stay engaged and adaptable in a dynamic, fast-paced environment.
Required Skills
* Bachelor’s degree (0-4+ years) or Master’s degree (0-2+ years) in chemistry or a related field. * Experience with RNA synthesis, chemical deprotection, and oligonucleotide purification is a plus. * Familiarity with analytical techniques such as UPLC, LC-MS, and UV-Vis is preferred. * Self-motivated, proactive, and team-oriented with a problem-solving mindset. * Organized, detail-oriented, and eager to learn and adapt.
Application Deadline: 2025-02-03
To apply for this job please visit jobrxiv.org.