1-617-500-6690 [email protected]

Korro Bio

Job Title: Associate Scientist/ Scientist I, Oligonucleotide Manufacturing

Job Number: 31287

Location: Cambridge, MA

Job Description

Korro Bio is seeking a passionate, driven, and creative chemist to join our oligonucleotide chemistry team and work with an enthusiastic team of highly skilled scientists in a dynamic, growing company. The successful candidate will have a strong background in oligonucleotide chemistry and will be responsible for the synthesis, purification and analysis of novel oligonucleotides and oligonucleotide conjugates to advance our RNA editing drug discovery programs. Candidate must express a high attention to detail, be comfortable multitasking and be able to function in an interdisciplinary and fast-paced startup environment.  

Responsibilities

  • Execute solid-phase synthesis, purification, and downstream processing of chemically modified oligonucleotides and oligonucleotides conjugates at different scales using modern automated oligo synthesis platforms 

  • Operate, maintain & troubleshoot equipment for oligonucleotide synthesis (ӒKTA Oligo Pilot), purification (ӒKTA Pure), desalting and lyophilization 

  • Maintain inventory of chemicals and amidites for oligonucleotide synthesis

  • Perform in-process and final analytics of oligonucleotide samples as needed

  • Track progress, analyze, organize, and present data to team and cross-functionally

  • Maintain a well-documented electronic laboratory notebook 

  • Actively participate in training activities and provide training to others as needed 

  • Author and review SOPs and technical reports

Required Skills

  • PhD in Chemistry, Biochemistry, Biotechnology, or related field with 1 year of experience or MS in Chemistry or relevant subject with at least 4 years of experience or BS in Chemistry or relevant subject with at least 6 years of experience in an industrial or academic setting and excellent understanding of nucleic acids and analytical chemistry. 

  • Hands-on experience in the synthesis, purification, solid-liquid conjugation, and analysis of oligonucleotides

  • Oligonucleotide process development experience is a plus

  • Strong laboratory skills and experience in handling, troubleshooting and routine maintenance of lab equipment including automated synthesis platforms, HPLC and LC-MS etc. 

  • High degree of flexibility and self-motivation in a fast-paced work environment with excellent organizational skills, ability to prioritize appropriately and meet deadlines. 

  • Excellent interpersonal, communication and presentation skills. 

 

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