Associate Scientist, Pharmacology

Job Title: Associate Scientist, Pharmacology

Job Number: 30238

Location: Cambridge, MA

Job Description

We are seeking a highly motivated Associate Scientist to join our Translational Pharmacology team. The Associate Scientist will have the opportunity to work with an enthusiastic team of highly skilled scientists in a dynamic, matrixed organized, high growth company.

Responsibilities

• Conduct experiments to determine the efficacy of novel oligonucleotides in models across a range of disease indications.
• Perform dosing (SC, IP and IV), monitor animal health, blood sampling, multiple tissue harvesting and data recording. Coordinate sample storage and analysis.
• Provide overall in vivo and ex vivo technical support for projects working to advance one or more experimental therapeutic compounds.
• Responsible for carefully documenting research and effectively communicating results across teams.
• Plan and execute in vivo studies in collaboration with research scientists.

Required Skills

• BA/BS or MS with 3-5 years’ experience in the biotechnology or pharmaceutical industry or academic equivalent.
• Knowledge of tissue processing and molecular biology methods (RNA purification, PCR, qPCR, sequencing, ELISA (MSD) and western blot).
• Experience running mouse models, including mouse handling, health monitoring, dosing and working with models of disease is highly desired.
• Skilled in various methods of dosing (IV, SC and IP), blood collection (tail vein/submandibular and cardiac puncture) and multiple tissue collection at necropsy for subsequent ex vivo
• Desire and drive to learn and understand the basic biologic mechanisms underpinning our products.
• Experience in oligonucleotide-based therapeutics or gene editing is a plus
• Relevant CNS related experience beneficial but not necessary
• Exposure to utilizing software such as Graph Pad Prism, Microsoft office, Excel, and electronic laboratory notebooks for data analysis and data summary.
• Excellent organizational, time management and data recording skills.
• Able to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines.
• Effective verbal and written communication skills.
• Detail-oriented and excellent problem-solving abilities.