• Contract
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Company:  Confidential

Job Title: Associate Scientist II (Contract)

Job Number: 34670


Job Description

An Associate Scientist II is sought to join a guide RNA chemistry team. The role entails hands-on work with long oligonucleotide purification and downstream processing to support gene editing drug discovery programs. The ideal candidate will have deep expertise in this area, work well in a fast-paced startup environment, and collaborate effectively with a skilled team of scientists.


  • Purify and analyze long oligonucleotides using chromatography.
  • Execute purification, analysis, and modification of guide RNAs.
  • Develop methods for oligonucleotide purification and analysis.
  • Support synthesis of modified guide RNA.
  • Operate and maintain laboratory equipment.
  • Prepare buffers accurately.
  • Track progress, generate updates, and present findings.
  • Maintain SOPs and electronic records.
  • Conduct experiments safely and efficiently.

Required Skills

  • Bachelor's degree in Chemistry or related field with 1 – 3 years of lab experience; or Master's degree in Chemistry or related field with 1 – 2 years of lab experience.
  • Experience in oligonucleotide purification and synthesis.
  • Strong analytical skills using LCMS, UPLC, and other techniques.
  • Proficient in lab instrumentation and maintenance.
  • Detail-oriented for high-quality RNA production.
  • Ability to work independently and in a team.
  • Flexibility in a fast-paced environment.
  • Proficiency in data analysis and lab record-keeping.
  • Strong communication and problem-solving skills.


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