Company:  Confidential

Job Title: Analytical Chemistry Contractor

Job Number: 34750

Location: Boston, MA

Job Description

The Natural Products/Analytical Chemist is a lab-based role and will have considerable hands-on experience in natural product (NP) discovery, isolation, chemical characterization, and de novo structural elucidation.

Responsibilities

  • Develop methods for novel NP compound discovery and isolation
  • Lead day-to-day hit compound ID, isolation and de novo structural elucidation
  • Help design and execute compound and extract screening assays
  • Maintain local chemistry instruments, including team’s LCMS and HPLCs
  • Manage team’s chemistry inventory
  • Lead chemistry CROs for additional compound isolation and structural elucidation. 

Required Skills

  • PhD in natural products chemistry, analytical chemistry, organic chemistry, or chemical engineering and minimum of 2+ years industry experience, or a BS/MS in these fields and a minimum of 6+ years industry experience.
  • Experience in the development and optimization of chemistry workflows for small molecule purification and characterization. 
  • Extensive experience analyzing LC/MS data, targeted and untargeted metabolomics.
  • Well-established experience in compound characterization using both 1D and 2D NMR techniques as well as small molecule crystallography and cryoEM
  • Deep understanding of natural product biosynthesis is preferred
  • Able to work independently in the lab, hands-on experience in operating state of art of analytical systems like LC-MS/MS
  • Experience in assaying the bioactivity of natural products and activity-guided fractionation is highly desirable.
  • Strong listening, writing, and communication skills.

 

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